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Titolo:
ACTIONS OF DAIICHI DQ-2511 ON ELECTRICAL AND SYNAPTIC BEHAVIOR OF ENTERIC NEURONS IN THE GUINEA-PIG SMALL-INTESTINE
Autore:
ZAFIROV D; XIA Y; FURUHAMA K; WOOD JD;
Indirizzi:
OHIO STATE UNIV,COLL MED,DEPT PHYSIOL,300 HAMILTON HALL,1645 NEIL AVECOLUMBUS OH 43210 OHIO STATE UNIV,COLL MED,DEPT PHYSIOL COLUMBUS OH 43210
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 311, anno: 1996,
pagine: 61 - 66
SICI:
0014-2999(1996)311:1<61:AODDOE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBMUCOSAL PLEXUS; CISAPRIDE;
Keywords:
GASTROINTESTINAL TRACT; INTESTINE; GANGLION; ENTERIC NERVOUS SYSTEM; MYENTERIC PLEXUS; SUBMUCOUS PLEXUS; GASTROINTESTINAL MOTILITY; INTESTINAL PROKINETIC DRUG; BENZAMIDE, SUBSTITUTED;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
D. Zafirov et al., "ACTIONS OF DAIICHI DQ-2511 ON ELECTRICAL AND SYNAPTIC BEHAVIOR OF ENTERIC NEURONS IN THE GUINEA-PIG SMALL-INTESTINE", European journal of pharmacology, 311(1), 1996, pp. 61-66

Abstract

Intracellular recording of electrical and synaptic behavior of neurons in the enteric nervous system of guinea-pig small intestine was usedto evaluate actions of DQ-2511 l)ethyl]carbamoyl]methyl]amino-N-methylbenzamide). DQ-2511 is a new drug with gastrointestinal prokinetic action. DQ-2511 was most effective in the nanomolar range. The drug depolarized some of the neurons and this was accompanied by increased input resistance and augmented excitability. DQ-2511 in nanomolar concentrations increased the amplitude of fast excitatory postsynaptic potentials at nicotinic synapses. Slow inhibitory postsynaptic potentials, produced by release of norepinephrine from sympathetic postganglionic fibers, were suppressed by DQ-2511. This appeared to reflect presynapticsuppression of release of norepinephrine because postsynaptic responses to exogenously applied norepinephrine were unaffected. The results suggest that the prokinetic action of DQ-2511 on gastrointestinal transit might emerge from actions that augment excitatory synaptic transmission in the microcircuits of the enteric nervous system while suppressing inhibitory sympathetic neurotransmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:13:45