Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF CITALOPRAM, A SELECTIVE SEROTONIN REUPTAKE INHIBITOR, ON THE ACQUISITION OF CONDITIONED FREEZING
Autore:
INOUE T; HASHIMOTO S; TSUCHIYA K; IZUMI T; OHMORI T; KOYAMA T;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PSYCHIAT,KITA KU,N 15,W 17 SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 311, anno: 1996,
pagine: 1 - 6
SICI:
0014-2999(1996)311:1<1:EOCASS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; PANIC DISORDER; ANIMAL-MODELS; DOUBLE-BLIND; FEAR STRESS; ANXIETY; FLUOXETINE; RECEPTORS; DOPAMINE; FLUVOXAMINE;
Keywords:
ANXIETY; CONDITIONED FEAR STRESS; FREEZING BEHAVIOR; 5-HT (5-HYDROXYTRYPTAMINE, SEROTONIN) REUPTAKE INHIBITOR, SELECTIVE CITALOPRAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
T. Inoue et al., "EFFECT OF CITALOPRAM, A SELECTIVE SEROTONIN REUPTAKE INHIBITOR, ON THE ACQUISITION OF CONDITIONED FREEZING", European journal of pharmacology, 311(1), 1996, pp. 1-6

Abstract

The present study examined the effects of the selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor citalopram on the acquisition of conditioned freezing, an index of anxiety. Acute treatment withcitalopram (1-10 mg/kg) dose dependently prevented the acquisition ofconditioned freezing, while acute treatment with noradrenaline or dopamine reuptake inhibitors failed. The acute effect of citalopram was not antagonized by the 5-HT1A receptor antagonist NAN190, 1-(2-methoxyphenyl)-4-[4-(2-phthalimmido butyl]piperazine or the 5-HT2A/2C receptorantagonist ICI169,369, 2-(2-dimethylaminoethylthio)-3-phenylquinolinehydrochloride. These results indicate or the 5-HT that selective 5-HTreuptake inhibitors reduce not only the expression of conditioned freezing as reported previously, but also the acquisition of conditioned freezing. Both these effects of selective 5-HT reuptake inhibitors maybe related to their clinical efficacy in the treatment of anxiety disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:05:38