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Titolo:
LATERAL HABENULAR INFLUENCE ON DORSAL RAPHE NEURONS
Autore:
FERRARO G; MONTALBANO ME; SARDO P; LAGRUTTA V;
Indirizzi:
UNIV PALERMO,IST FISIOL UMANA,CORSO TUKORY 129 I-90134 PALERMO ITALY UNIV PALERMO,IST FISIOL UMANA I-90134 PALERMO ITALY UNIV PALERMO,DEPT CELLULAR BIOL & GROWTH,LAB GEN PHYSIOL I-90134 PALERMO ITALY
Titolo Testata:
Brain research bulletin
fascicolo: 1, volume: 41, anno: 1996,
pagine: 47 - 52
SICI:
0361-9230(1996)41:1<47:LHIODR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL THETA-RHYTHM; SEROTONERGIC NEURONS; MIDBRAIN RAPHE; HORSERADISH-PEROXIDASE; NUCLEUS; RAT; INHIBITION; PROJECTION; GABA; TRANSMISSION;
Keywords:
LATERAL HABENULA STIMULATION; DORSAL RAPHE NEURONS; IONTOPHORESIS; NMDA; 2-APV; GABA; BICUCULLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G. Ferraro et al., "LATERAL HABENULAR INFLUENCE ON DORSAL RAPHE NEURONS", Brain research bulletin, 41(1), 1996, pp. 47-52

Abstract

Previously, we have demonstrated that lateral habenula (LH) modulatesthe bioelectric activity of the hippocampus through the dorsal raphe nucleus functional involvement. In this study we have, preliminarily, electrophysiologically identified two types of raphe neurons: ''slow''(S cells, serotonergic in nature); and ''fast'' (F cells, presumably GABAergic in nature). Then, we have shown that LH electrical stimulation at lower frequency induced an excitation of S and F neurons. LH stimulation at higher frequency inhibited only S neurons. Furthermore, iontophoretic NMDA excited S and F neurons. The excitatory effects of LHstimulation were antagonized by the iontophoretic 2-APV (NMDA antagonist). Iontophoretic GABA inhibited only S neurons. Iontophoretic bicuculline antagonized the LH-induced inhibition of S neurons. The data suggested a direct (NMDA-mediated) and indirect (through the F GABAergicinhibitory interneuron) influence of the LH on the serotonergic efferent neuron.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:53:14