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Titolo:
NEONATAL ISOLATION ALTERS LTP IN FREELY MOVING JUVENILE RATS - SEX-DIFFERENCES
Autore:
BRONZINO JD; KEHOE P; AUSTINLAFRANCE RJ; RUSHMORE RJ; KURDIAN J;
Indirizzi:
TRINITY COLL,DEPT ENGN & COMP SCI,NEUROSCI PROGRAM,300 SUMMIT ST HARTFORD CT 06106
Titolo Testata:
Brain research bulletin
fascicolo: 3, volume: 41, anno: 1996,
pagine: 175 - 183
SICI:
0361-9230(1996)41:3<175:NIALIF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RABBIT FOLLOWING STIMULATION; GUINEA-PIG PUPS; MATERNAL SEPARATION; STRESS IMPAIRS; SYNAPTIC TRANSMISSION; LASTING POTENTIATION; HIPPOCAMPAL DAMAGE; PYRAMIDAL NEURONS; DOPAMINE RELEASE;
Keywords:
HIPPOCAMPUS; DENTATE GYRUS; NEONATAL STRESS; NEUROPLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Bronzino et al., "NEONATAL ISOLATION ALTERS LTP IN FREELY MOVING JUVENILE RATS - SEX-DIFFERENCES", Brain research bulletin, 41(3), 1996, pp. 175-183

Abstract

We have previously reported that neonatal isolation significantly enhanced the magnitude of hippocampal longterm potentiation (LTP) recorded from freely moving male rats tested at 30 days of age. The present study extends this work to examine the effects of neonatal isolation onhippocampal LTP in male and female juvenile rats. Changes in dentate granule cell population measures, i.e., EPSP slope and population spike amplitude (PSA), evoked by tetanization of the medial perforant pathway were used to assess the effects of neonatal isolation on LTP over a period of 96 hrs, Prior to tetanization, significant sex differenceswere obtained for input/output (I/O) response measures of EPSP slope and PSA, with males showing consistently higher values than females. No significant effect of treatment was obtained within either sex for baseline measures. Following tetanization significant sex differences were also obtained for both measures, with males showing significantly greater enhancement than females, Comparisons made at 1 hr post-tetanization (establishment of LTP) indicated that isolated males showed significantly greater enhancement than any other group. On the other hand, treatment differences were not obtained from females. At 96 hrs (maintenance of LTP), however, both neonatally isolated males and females showed significantly greater enhancement than either non-isolated siblings or unhandled controls, These results indicate that males and females exhibit different enhancement profiles with respect to both the magnitude and duration of LTP, and that neonatal isolation alters these profiles in a sex-specific manner.

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Documento generato il 20/01/20 alle ore 16:16:10