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Titolo:
COSTIMULATORY MOLECULE-DEFICIENT DENDRITIC CELL PROGENITORS (MHC CLASS II-)) PROLONG CARDIAC ALLOGRAFT SURVIVAL IN NONIMMUNOSUPPRESSED RECIPIENTS(, CD80(DIM), CD86()
Autore:
FU FM; LI YP; QIAN SG; LU LN; CHAMBERS F; STARZL TE; FUNG JJ; THOMSON AW;
Indirizzi:
UNIV PITTSBURGH,MED CTR,PITTSBURGH TRANSPLANT INST,W1544 BIOMED SCI TOWER,200 LOTHROP ST PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT SURG PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT MOL GENET PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT BIOCHEM PITTSBURGH PA 15213
Titolo Testata:
Transplantation
fascicolo: 5, volume: 62, anno: 1996,
pagine: 659 - 665
SICI:
0041-1337(1996)62:5<659:CMDCP(>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; CTLA-4 COUNTER-RECEPTOR; BONE-MARROW; MONOCLONAL-ANTIBODY; TRANSPLANTATION TOLERANCE; GRAFT ACCEPTANCE; LANGERHANS CELLS; IN-VITRO; LIVER; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
F.M. Fu et al., "COSTIMULATORY MOLECULE-DEFICIENT DENDRITIC CELL PROGENITORS (MHC CLASS II-)) PROLONG CARDIAC ALLOGRAFT SURVIVAL IN NONIMMUNOSUPPRESSED RECIPIENTS(, CD80(DIM), CD86()", Transplantation, 62(5), 1996, pp. 659-665

Abstract

We have shown previously that granulocyte-macrophage colony-stimulating factor-stimulated mouse bone marrow-derived MHC class II+ dendriticcell (DC) progenitors that are deficient in cell surface expression of the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) can induce alloantigen-specific T-cell anergy in vitro. To test the in vivo relevance of these findings, 2 x 10(6) B10 (H2(b)) mouse bone marrow-derivedDC progenitors (NLDC 145(+), MHC class II+, B7-1(dim) B7-2(-/dim)) that induced T-cell hyporesponsiveness in vitro were injected systemically into normal C3H (H2(k)) recipients. Seven days later, the mice received heterotopic heart transplants from B10 donors, No immunosuppressive treatment was given, Median graft survival time was prolonged significantly from 9.5 to 22 days, Median graft survival time was also increased, although to a lesser extent (16.5 days), in mice that received third-party (BALB/c; H2(d)) DC progenitors, Ex vivo analysis of host T-cell responses to donor and third-party alloantigens 7 days after theinjection of DC progenitors (the time of heart transplant) revealed minimal anti-donor mixed leukocyte reaction and cytotoxic T lymphocyte reactivity, These responses were reduced substantially compared with those of spleen cells from animals pretreated with ''mature'' granulocyte-macrophage colony-stimulating factor + interleukin-4-stimulated DC (MHC class IIbright, B7-1(+), B7-2(bright)), many of which rejected their heart grafts in an accelerated fashion, Among the injected donor MHC class II+ DC progenitors that migrated to recipient secondary lymphoid tissue were cells that appeared to have up-regulated cell surface B7-1 and B7-2 molecule expression. This observation may explain, at least in part, the temporary or unstable nature of the hyporesponsiveness induced by the DC progenitors in nonimmunosuppressed recipients.

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Documento generato il 19/09/20 alle ore 14:28:58