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Titolo:
FUNCTIONAL-RELATIONSHIPS BETWEEN NOTCH, SU(H) AND THE BHLH GENES OF THE E(SPL) COMPLEX - THE E(SPL) GENES MEDIATE ONLY A SUBSET OF NOTCH ACTIVITIES DURING IMAGINAL DEVELOPMENT
Autore:
DECELIS JF; DECELIS J; LIGOXYGAKIS P; PREISS A; DELIDAKIS C; BRAY S;
Indirizzi:
UNIV CAMBRIDGE,DEPT ANAT,DOWNING ST CAMBRIDGE CB2 1TN ENGLAND UNIV CAMBRIDGE,DEPT ANAT CAMBRIDGE CB2 1TN ENGLAND UNIV CAMBRIDGE,DEPT GENET CAMBRIDGE CB2 1TN ENGLAND FDN RES & TECHNOL HELLAS,INST MOL BIOL & BIOTECHNOL IRAKLION CRETE GREECE UNIV CRETE,DEPT BIOL IRAKLION CRETE GREECE UNIV HOHENHEIM,INST ALLGEMEINE GENET D-7000 STUTTGART GERMANY
Titolo Testata:
Development
fascicolo: 9, volume: 122, anno: 1996,
pagine: 2719 - 2728
SICI:
0950-1991(1996)122:9<2719:FBNSAT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACHAETE-SCUTE COMPLEX; LOOP-HELIX PROTEINS; OF-SPLIT COMPLEX; DROSOPHILA-MELANOGASTER; PRONEURAL CLUSTERS; EARLY NEUROGENESIS; CELL FATES; ENHANCER; EXPRESSION; LOCUS;
Keywords:
DROSOPHILA; NOTCH; SUPPRESSOR OF HAIRLESS; ENHANCER OF SPLIT; TRANSCRIPTION; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Decelis et al., "FUNCTIONAL-RELATIONSHIPS BETWEEN NOTCH, SU(H) AND THE BHLH GENES OF THE E(SPL) COMPLEX - THE E(SPL) GENES MEDIATE ONLY A SUBSET OF NOTCH ACTIVITIES DURING IMAGINAL DEVELOPMENT", Development, 122(9), 1996, pp. 2719-2728

Abstract

The basic helix-loop-helix proteins of the Enhancer of split complex constitute a link between activation of the transmembrane receptor Notch and the resulting effects on transcription of downstream genes, TheSuppressor of Hairless protein is the intermediary between Notch activation and expression of all Enhancer of split genes even though individual genes have distinct patterns of expression in imaginal discs, A comparison between the phenotypes produced by Notch, Suppressor of Hairless and Enhancer of split mutations in the wing and thorax indicate that Suppressor of Hairless and Notch requirements are indistinguishable, but that Enhancer of split activity is only essential for a subsetof developmental processes involving Notch function. Likewise, the ectopic expression of sequences typical of ectopic Notch activation. We suggest that the Notch pathway bifurcates after the activation of Suppressor of Hairless and that Enhancer of split activity is not requiredwhen the consequence of Notch function is the transcriptional activation of downstream genes. Transcriptional activation mediated by Suppressor of Hairless and transcriptional repression mediated by Enhancer of split could provide greater diversity in the response of individual genes to Notch activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:19:02