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Titolo:
GENETIC-FACTORS AFFECTING THE CONSISTENCY AND MAGNITUDE OF CHANGES INPLASMA-CHOLESTEROL IN RESPONSE TO DIETARY CHALLENGE
Autore:
HUMPHRIES SE; TALMUD PJ; COX C; SUTHERLAND W; MANN J;
Indirizzi:
UNIV LONDON UNIV COLL,RAYNE INST,SCH MED,DEPT MED,DIV CARDIOVASC GENET,UNIV ST LONDON WC1E 6JJ ENGLAND UNIV OTAGO,DEPT HUMAN NUTR OTAGO NEW ZEALAND
Titolo Testata:
Quarterly Journal of Medicine
fascicolo: 9, volume: 89, anno: 1996,
pagine: 671 - 680
SICI:
1460-2725(1996)89:9<671:GATCAM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN-LIPASE GENE; AI-CIII-AIV; LOW-DENSITY-LIPOPROTEIN; FAMILIAL COMBINED HYPERLIPIDEMIA; MYOCARDIAL-INFARCTION SURVIVORS; B-CONTAINING LIPOPROTEINS; APOLIPOPROTEIN-B; APO-CIII; CORONARY ATHEROSCLEROSIS; TRANSGENIC MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Humphries et al., "GENETIC-FACTORS AFFECTING THE CONSISTENCY AND MAGNITUDE OF CHANGES INPLASMA-CHOLESTEROL IN RESPONSE TO DIETARY CHALLENGE", Quarterly Journal of Medicine, 89(9), 1996, pp. 671-680

Abstract

We examined the role of common genetic variation in determining the consistency and magnitude of change in plasma total cholesterol (TC) levels in response to two separate changes from a high-saturated (SFA) to a low-saturated/high-polyunsaturated-fat (PUFA) diet, in a group of free-living healthy men and women. Consistent responders were defined as those whose mean difference in the change in TC was within one SD of the mean for all participants, and the remainder were defined as variable responders. DNA was obtained from 55 individuals and genotype determined at the apolipoprotein (ape) B locus (signal peptide, SP), apoCIII (C1100-T) and lipoprotein lipase (LPL) gene loci (HindIII). In the 38 consistent responders, the apoBSP24 allele was significantly morecommon than in the 17 individuals with a variable response (0.29 vs. 0.12; p<0.05). No other polymorphism showed a significant frequency difference between groups. In the group as a whole, the correlation between the change in TC level in response to the first and second dietarychange was 0.28 (p=0.05), but those with one or more apoB SP24 alleles and those with the apoCIII genotype CC had a significantly higher correlation than those with other genotypes (0.46 (p=0.05) vs. 0.12 (NS)and 0.31 (p=0.05) vs. 0.02 (NS), respectively). In the group as a whole, mean response left TC 10% higher on the SFA than on the PUFA diet,and neither apoB nor apoCIII genotypes affected the magnitude of thisresponse. However, individuals with the LPL HindIII genotype H+H+ hada significantly smaller change in mean TC in response to diet than those with one or more H- allele (9.3% vs. 14.4%; p=0.03). Thus variation at the apoB and apoCIII loci affects the consistency of response to change in dietary fat content, while variation at the LPL gene locus affects magnitude of response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:35:19