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Titolo:
COMPARISON BETWEEN URINARY PYRIDINIUM CROSS-LINKS AND HYDROXYLYSINE GLYCOSIDES IN MONITORING THE EFFECTS OF OVARIECTOMY AND 17-BETA-ESTRADIOL REPLACEMENT IN AGED RATS
Autore:
PECILE A; NETTI C; SIBILIA V; VILLA I; CALORI G; TENNI R; COLUZZI M; MORO GL; RUBINACCI A;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & MED TOXICOL,VANVITELLI 32 I-20129 MILAN ITALY SAN RAFFAELE SCI INST,BONE METAB UNIT I-20132 MILAN ITALY SAN RAFFAELE SCI INST,EPIDEMIOL UNIT I-20132 MILAN ITALY UNIV PAVIA,DEPT BIOCHEM A CASTELLANI I-27100 PAVIA ITALY
Titolo Testata:
Journal of Endocrinology
fascicolo: 3, volume: 150, anno: 1996,
pagine: 383 - 390
SICI:
0022-0795(1996)150:3<383:CBUPCA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE LOSS; COLLAGEN; TURNOVER; BIOSYNTHESIS; EXCRETION; DISORDERS; MODEL; MASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Pecile et al., "COMPARISON BETWEEN URINARY PYRIDINIUM CROSS-LINKS AND HYDROXYLYSINE GLYCOSIDES IN MONITORING THE EFFECTS OF OVARIECTOMY AND 17-BETA-ESTRADIOL REPLACEMENT IN AGED RATS", Journal of Endocrinology, 150(3), 1996, pp. 383-390

Abstract

This study was undertaken to assess the sensitivity of hydroxylysylpyridinoline (HP), lysylpyridinoline (LP), galactosylhydroxylysine (GHyl) and glucosylgalactosyl-hydroxylysine (GGHyl) to monitor bone response to estrogen deficiency and replacement by comparing their excretory patterns in ovariectomized aged (11-14 months old) rats. The ovariectomized (OVX) rats were randomized into two groups: (1) OVX plus vehicle; (2) OVX plus 17 beta-estradiol (17-beta E, 10 mu g/kg, s.c., 4 days/week). Treatment with 17-beta E started immediately after OVX and continued for 60 days. The collagen catabolites were measured in urine for1 month before OVX and thereafter for 60 days. In temporal coincidence with urine collection, bone area and bone mineral density (BMD) of lumbar vertebrae, femoral diaphysis and distal metaphysis were measuredby dual-energy X-ray absorptiometry. In the untreated rats, BMD of the femoral metaphysis and lumbar vertebrae decreased significantly and the urinary excretion of LP, HP, GHyl and GGHyl increased with different patterns. In the treated rats, 17-beta E replacement prevented the increment in LP excretion, partially prevented the increase in HP excretion, but had no effect on the excretion of GHyl and GGHyl. III conclusion pyridinolines and glycosides have different sensitivities to thebone response to OVX. Glycoside excretion after OVX also reflects metabolic processes not strictly related to bone loss and, ill contrast with LP, is not sensitive to estrogen replacement.

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Documento generato il 19/02/20 alle ore 22:15:56