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Titolo:
MOLECULAR ANALYSIS OF MEDULLOBLASTOMAS OCCURRING SIMULTANEOUSLY IN MONOZYGOTIC TWINS
Autore:
SCHEURLEN W; SORENSEN N; ROGGENDORF W; KUHL J;
Indirizzi:
UNIV WURZBURG,DEPT PAEDIAT,JOSEF SCHEIDER STR 2 D-97080 WURZBURG GERMANY UNIV WURZBURG,DEPT PAEDIAT NEUROSURG D-97080 WURZBURG GERMANY UNIV WURZBURG,DEPT NEUROPATHOL D-97080 WURZBURG GERMANY
Titolo Testata:
European journal of pediatrics
fascicolo: 10, volume: 155, anno: 1996,
pagine: 880 - 884
SICI:
0340-6199(1996)155:10<880:MAOMOS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; NERVOUS-SYSTEM TUMORS; CYTOGENETIC ANALYSIS; CHROMOSOME 17P13.3; GORLIN SYNDROME; BRAIN-TUMORS; CHILDHOOD; HETEROZYGOSITY; HYBRIDIZATION; LINKAGE;
Keywords:
MEDULLOBLASTOMA; MONOZYGOTIC TWINS; LOSS OF HETEROZYGOSITY; CHROMOSOME 17P13 AND 9Q31;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
W. Scheurlen et al., "MOLECULAR ANALYSIS OF MEDULLOBLASTOMAS OCCURRING SIMULTANEOUSLY IN MONOZYGOTIC TWINS", European journal of pediatrics, 155(10), 1996, pp. 880-884

Abstract

We report male monocygotic twins with concordant desmoplastic medulloblastoma diagnosed al the age of 20 months, Both tumours were completely removed. As chromosomal loci 17p13 and 9q31 are frequently altered in medulloblastoma these regions were analysed in both tumours in detail using restriction fragment length polymorphism and microsatellite analysis. No common aberration was found. The c-myc gene on chromosome 8q21 was not amplified. Conclusion Although a common genetic defect has not been found in our patients' tumours the clinical presentation supports the assumption of an inherited genetic predisposition to develop medulloblastoma in at least some cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:12:57