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Titolo:
DIFFERENTIAL EXPRESSION OF DESMOSOMAL GLYCOPROTEINS IN KERATOACANTHOMA AND SQUAMOUS-CELL CARCINOMA OF THE SKIN - AN IMMUNOHISTOCHEMICAL AIDTO DIAGNOSIS
Autore:
KRUNIC ALJ; GARROD DR; SMITH NP; ORCHARD GS; CVIJETIC OB;
Indirizzi:
DUKE UNIV,MED CTR,DEPT MED,DIV DERMATOL,DERMATOL SURG UNIT,BOX 3915 DURHAM NC 27710 UNIV MANCHESTER,SCH BIOL SCI,EPITHELIAL MORPHOGENESIS RES GRP MANCHESTER LANCS ENGLAND ST THOMAS HOSP,ST JOHNS INST SKIN DIS,DEPT DERMATOPATHOL LONDON ENGLAND UNIV BELGRADE,SCH MED,DEPT DERMATOL BELGRADE YUGOSLAVIA
Titolo Testata:
Acta dermato-venereologica
fascicolo: 5, volume: 76, anno: 1996,
pagine: 394 - 398
SICI:
0001-5555(1996)76:5<394:DEODGI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEMPHIGUS-FOLIACEUS SERA; BOVINE DESMOGLEIN-1; BCL-2 EXPRESSION; ANTIGENS; VULGARIS; TUMORS; DOMAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A.L.J. Krunic et al., "DIFFERENTIAL EXPRESSION OF DESMOSOMAL GLYCOPROTEINS IN KERATOACANTHOMA AND SQUAMOUS-CELL CARCINOMA OF THE SKIN - AN IMMUNOHISTOCHEMICAL AIDTO DIAGNOSIS", Acta dermato-venereologica, 76(5), 1996, pp. 394-398

Abstract

The distinction between keratoacanthoma and squamous cell carcinoma is a common dermatopathological dilemma. Although the mainstay of the diagnosis is still clinico-pathological correlation, many dermatopathologists now include keratoacanthomas in the spectrum of squamous cell carcinomas, Recent reports, however, have pointed out that keratoacanthoma is ''deficient squamous cell carcinoma'' since it loses the expression of bcl-2 antigen, consistent with initiation of apoptosis, i.e, its involution, Electron microscope studies performed in keratoacanthomas and squamous cell carcinomas also revealed significantly reduced desmosomes in squamous cell carcinoma, but not in keratoacanthoma. A series of 38 keratoacanthomas and 62 squamous cell carcinomas of the skin(28 well-differentiated, 21 moderately differentiated and 13 poorly differentiated) were stained immunohistochemically with the monoclonal antibody 32-2B to desmosomal glycoproteins desmoglein 1 and desmoglein3. Thirty-five keratoacanthomas showed extensive pericellular desmoglein expression Three keratoacanthomas and 28 squamous cell carcinomass(19 well-differentiated, 1 moderately differentiated) showed focal staining, and in 11 squamous cell carcinomas (2 moderately differentiated, 9 poorly differentiated) the staining was negative, The remaining 31 squamous cell carcinomas (9 well differentiated, 18 moderately differentiated, 4 poorly differentiated) showed juxtanuclear staining, Noneof the squamous cell carcinomas exhibited the extensive pericellular pattern found in keratoacanthomas. Assessment of staining intensity, by 3 independent examiners, revealed a strong negative correlation between desmoglein expression and degree of dysplasia in the squamous cellcarcinomas (p<0.01). This antibody therefore clearly distinguishes these tumours and may be of value in the differential diagnosis of keratoacanthoma and squamous cell carcinomas in routine histopathology.

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Documento generato il 24/11/20 alle ore 22:37:28