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Titolo:
IDENTIFICATION OF VASCULAR ENDOTHELIAL GENES DIFFERENTIALLY RESPONSIVE TO FLUID MECHANICAL STIMULI - CYCLOOXYGENASE-2, MANGANESE SUPEROXIDE-DISMUTASE, AND ENDOTHELIAL-CELL NITRIC-OXIDE SYNTHASE ARE SELECTIVELYUP-REGULATED BY STEADY LAMINAR SHEAR-STRESS
Autore:
TOPPER JN; CAI JX; FALB D; GIMBRONE MA;
Indirizzi:
BRIGHAM & WOMENS HOSP,DEPT PATHOL,DIV VASC RES,221 LONGWOOD AVE,ROOM 401 BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT PATHOL,DIV VASC RES BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT MED,DIV CARDIOVASC BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115 MILLENNIUM PHARMACEUT INC CAMBRIDGE MA 02139
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 19, volume: 93, anno: 1996,
pagine: 10417 - 10422
SICI:
0027-8424(1996)93:19<10417:IOVEGD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKOCYTE ADHESION MOLECULE; FACTOR-KAPPA-B; CULTURED HUMAN; CAROTID BIFURCATION; EPITHELIAL-CELLS; MESSENGER-RNA; EXPRESSION; ATHEROSCLEROSIS; FLOW; INDUCTION;
Keywords:
ATHEROSCLEROSIS; VASCULAR ENDOTHELIUM; HEMODYNAMIC FORCES; DIFFERENTIAL DISPLAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
J.N. Topper et al., "IDENTIFICATION OF VASCULAR ENDOTHELIAL GENES DIFFERENTIALLY RESPONSIVE TO FLUID MECHANICAL STIMULI - CYCLOOXYGENASE-2, MANGANESE SUPEROXIDE-DISMUTASE, AND ENDOTHELIAL-CELL NITRIC-OXIDE SYNTHASE ARE SELECTIVELYUP-REGULATED BY STEADY LAMINAR SHEAR-STRESS", Proceedings of the National Academy of Sciences of the United Statesof America, 93(19), 1996, pp. 10417-10422

Abstract

Early atherosclerotic lesions develop in a topographical pattern thatstrongly suggests involvement of hemodynamic forces in their pathogenesis. We hypothesized that certain endothelial genes, which exhibit differential responsiveness to distinct fluid mechanical stimuli, may participate in the atherogenic process by modulating, on a local level within the arterial wall, the effects of systemic risk factors, A differential display strategy using cultured human endothelial cells has identified two genes, manganese superoxide dismutase and cyclooxygenase-2, that exhibit selective and sustained up-regulation by steady laminar shear stress (LSS). Turbulent shear stress, a nonlaminar fluid mechanical stimulus, does not induce these genes, The endothelial form of nitric oxide synthase also demonstrates a similar LSS-selective patternof induction. Thus, three genes with potential atheroprotective (antioxidant, antithrombotic, and antiadhesive) activities manifest a differential response to distinct fluid mechanical stimuli, providing a possible mechanistic link between endothelial gene expression and early events in atherogenesis. The activities of these and other LSS-responsive genes may have important implications for the pathogenesis and prevention of atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 07:44:19