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Titolo:
ASSEMBLY OF THE CARDIAC I-BAND REGION OF TITIN CONNECTIN - EXPRESSIONOF THE CARDIAC-SPECIFIC REGIONS AND THEIR STRUCTURAL RELATION TO THE ELASTIC SEGMENTS/
Autore:
GAUTEL M; LEHTONEN E; PIETRUSCHKA F;
Indirizzi:
EUROPEAN MOL BIOL LAB,BIOL STRUCT DIV,POSTFACH 102209 D-69012 HEIDELBERG GERMANY UNIV HELSINKI,DEPT PATHOL HELSINKI FINLAND MAX PLANCK INST MOL PHYSIOL DORTMUND GERMANY
Titolo Testata:
Journal of muscle research and cell motility
fascicolo: 4, volume: 17, anno: 1996,
pagine: 449 - 461
SICI:
0142-4319(1996)17:4<449:AOTCIR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-MESENCHYMAL INTERACTIONS; IMMUNOGLOBULIN-TYPE DOMAINS; SKELETAL-MUSCLE; IMMUNOELECTRON MICROSCOPY; MONOCLONAL-ANTIBODIES; STRIATED-MUSCLE; VERTEBRATE SKELETAL; CONNECTIN FILAMENTS; TITIN FILAMENTS; PASSIVE TENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M. Gautel et al., "ASSEMBLY OF THE CARDIAC I-BAND REGION OF TITIN CONNECTIN - EXPRESSIONOF THE CARDIAC-SPECIFIC REGIONS AND THEIR STRUCTURAL RELATION TO THE ELASTIC SEGMENTS/", Journal of muscle research and cell motility, 17(4), 1996, pp. 449-461

Abstract

The giant molecule titin (also called connectin) provides an elastic connection in the I-band between the Z-disk and A-band of striated muscle. This region is assembled in a tissue-specific way by extensive differential splicing events. We have raised monoclonal antibodies against the two N2-line isoforms of titin and demonstrate that both forms of cardiac I-band titin are constitutively co-expressed in atrial and ventricular muscle. In developing mouse embryos, the expression of the cardiac N2-B isoform remains strictly cardiac-specific and is linked to the expression of the ubiquitous N2-A isoform. The mechanical function of the cardiac N2-line region was investigated ultrastructurally. Immunoelectron microscopy reveals that the N2-B region separates two mechanically distinct sections of titin with a hyperextensible segment spanning the distance to the Z-disk. The formation of a plateau in the extension of cardiac titin rules out that Ig-domains can be unfolded as a mechanism of elasticity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 08:13:36