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Titolo:
INVOLVEMENT OF THE 12-LIPOXYGENASE PATHWAY OF ARACHIDONIC-ACID METABOLISM IN HOMOSYNAPTIC LONG-TERM DEPRESSION OF THE RAT HIPPOCAMPUS
Autore:
NORMANDIN M; GAGNE J; BERNARD J; ELIE R; MICELI D; BAUDRY M; MASSICOTTE G;
Indirizzi:
UNIV QUEBEC,DEPT CHIM BIOL,CP 500 TROIS RIVIERES PQ G9A 5H7 CANADA UNIV QUEBEC,DEPT CHIM BIOL TROIS RIVIERES PQ G9A 5H7 CANADA UNIV QUEBEC,DEPT PSYCHOL TROIS RIVIERES PQ G9A 5H7 CANADA CTR RECH FERNAND SEGUIN MONTREAL PQ H1N 3M5 CANADA UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 730, anno: 1996,
pagine: 40 - 46
SICI:
0006-8993(1996)730:1-2<40:IOT1PO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR CURRENTS; NITRIC-OXIDE; SYNAPTIC TRANSMISSION; AREA CA1; PHOSPHOLIPASE-A2 TREATMENT; LIPOXYGENASE METABOLITES; QUISQUALATE RECEPTORS; RETROGRADE MESSENGER; GLUTAMATE RECEPTORS; POTENTIATION;
Keywords:
HIPPOCAMPUS; LONG-TERM DEPRESSION; PHOSPHOLIPASE A(2); ARACHIDONIC ACID; 12-LIPOXYGENASE METABOLITE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
M. Normandin et al., "INVOLVEMENT OF THE 12-LIPOXYGENASE PATHWAY OF ARACHIDONIC-ACID METABOLISM IN HOMOSYNAPTIC LONG-TERM DEPRESSION OF THE RAT HIPPOCAMPUS", Brain research, 730(1-2), 1996, pp. 40-46

Abstract

Low-frequency stimulation is associated with long-term depression (LTD) of synaptic efficacy in various brain structures. Like long-term potentiation (LTP), homosynaptic LTD in area CA1 of the hippocampus appears to require NMDA receptor activation, changes in postsynaptic calcium concentration and phospholipase A(2) (PLA(2)) activation. Arachidonic acid (AA) is released after the activation of calcium-dependent phospholipases and free AA is rapidly metabolized to a family of bioactive products (the eicosanoids) which are thought to be both intracellular and extracellular messengers. In the present study, we investigated the involvement of the cyclooxygenase and lipoxygenase pathways of AA metabolism in the formation of homosynaptic LTD in the rat hippocampus. Stimulation at 1 Hz for 15 min was used to produce homosynaptic depression in area CA1 of hippocampal slices. LTD induction was partially blocked by bromophenacyl bromide (50-100 mu M), a selective PLA(2) inhibitor, and by the a nonselective lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA; 100 mu M). In contrast, the specific cyclooxygenase blocker indomethacin (100 mu M) did not significantly reduce hippocampal LTD. Since NDGA interferes with LTD formation, we examined whether specific inhibitors of 5- and 12-lipoxygenases were capable of blocking LTD expression, The 12-lipoxygenase inhibitor baicalein at a concentration of 50 mu M reduced LTP formation when given in the bath, an effect that was less pronounced with the 5-lipoxygenase inhibitor AA-861. These data suggest that the activation of endogenous PLA(2) and theformation of 12-lipoxygenase metabolites of AA may be important factors controlling the expression of hippocampal LTD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:55:42