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Titolo:
BARORECEPTOR MODULATION OF REGIONAL HEMODYNAMIC-RESPONSES TO ACUTE STRESS IN RAT
Autore:
ZHANG ZQ; JULIEN C; BARRES C;
Indirizzi:
FAC PHARM LYON,URA CNRS 1483,DEPT PHYSIOL & PHARMACOL CLIN,8 AVE ROCKEFELLER F-69373 LYON 08 FRANCE FAC PHARM LYON,URA CNRS 1483,DEPT PHYSIOL & PHARMACOL CLIN F-69373 LYON 08 FRANCE
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1-2, volume: 60, anno: 1996,
pagine: 23 - 30
SICI:
0165-1838(1996)60:1-2<23:BMORHT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL-PRESSURE LABILITY; SPONTANEOUSLY HYPERTENSIVE RATS; SINOAORTIC-DENERVATED RATS; SYMPATHETIC ACTIVITY; HEMODYNAMIC ANALYSIS; ENDOCRINE RESPONSES; VASCULAR-RESISTANCE; BEHAVIORAL STRESS; DEFENSE REACTION; HEART-RATE;
Keywords:
BETA-ADRENOCEPTORS; HEMODYNAMICS; SINOAORTIC DENERVATION; STRESS; VASODILATATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
Z.Q. Zhang et al., "BARORECEPTOR MODULATION OF REGIONAL HEMODYNAMIC-RESPONSES TO ACUTE STRESS IN RAT", Journal of the autonomic nervous system, 60(1-2), 1996, pp. 23-30

Abstract

We examined the effects of chronic sinoaortic denervation (SAD) on regional haemodynamic responses to acute environmental stress in rats. In conscious male intact (n = 12) and SAD (2 weeks before study, n = 7)rats, arterial pressure and blood flow velocities (pulsed Doppler probes) in the subdiaphragmatic aorta, superior mesenteric artery and distal aorta (hindquarters) were simultaneously recorded. in response to air jet stress, intact rats showed modest increases in arterial pressure that were accompanied by vasoconstriction in the mesentery and vasodilatation in the hindquarters. These regional haemodynamic changes were almost balanced, as indicated by the lack of change in the subdiaphragmatic aortic conductance. SAD markedly enhanced the presser and mesenteric vasoconstrictor responses and blunted the hindquarters vasodilatation. After acute beta-adrenoceptor blockade with propranolol, the stress-induced hindquarters vasodilatation was strongly reduced in theintact rats and was reversed into vasoconstriction in the SAD rats. These results point to an opposing interaction between centrally-induced sympathoexcitation and arterial baroreceptor reflex activation during stress. This probably favours the hyperaemic response in the skeletal muscles at a lower metabolic cost.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 00:47:30