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Titolo:
EFFECT OF MK-801 ON PRIMING OF D-1-DEPENDENT CONTRALATERAL TURNING AND ITS RELATIONSHIP TO C-FOS EXPRESSION IN THE RAT CAUDATE-PUTAMEN
Autore:
MORELLI M; FENU S; CARTA A; DICHIARA G;
Indirizzi:
UNIV CAGLIARI,DEPT TOXICOL,VIALE A DIAZ 182 I-09126 CAGLIARI ITALY UNIV CAGLIARI,DEPT TOXICOL I-09126 CAGLIARI ITALY UNIV CAGLIARI,CNR,CTR NEUROPHARMACOL I-09126 CAGLIARI ITALY
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 79, anno: 1996,
pagine: 93 - 100
SICI:
0166-4328(1996)79:1-2<93:EOMOPO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
6-HYDROXYDOPAMINE LESIONED RATS; DOPAMINE DEPLETION; MESSENGER-RNA; SENSITIZATION; MK-801; AMPHETAMINE; BEHAVIOR; AGONIST; COCAINE; RECEPTORS;
Keywords:
MK 801; SKF 38393; APOMORPHINE; 6-HYDROXYDOPAMINE LESION; CONTRALATERAL TURNING; DOPAMINE DEPENDENCE; C-FOS EXPRESSION; CAUDATE-PUTAMEN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Morelli et al., "EFFECT OF MK-801 ON PRIMING OF D-1-DEPENDENT CONTRALATERAL TURNING AND ITS RELATIONSHIP TO C-FOS EXPRESSION IN THE RAT CAUDATE-PUTAMEN", Behavioural brain research, 79(1-2), 1996, pp. 93-100

Abstract

In rats with a unilateral 6-hydroxydopamine lesion of the ascending dopamine neurons, we investigated the relationship between the expression of Fos-like immunoreactivity in the caudate-putamen and contralateral turning behavior in response to dopamine agonists during the induction and expression of sensitization (priming) to D-1-dependent turningbehavior. Priming was induced by apomorphine (0.1 mg/kg s.c.) or by SKF 38393 (10 mg/kg s.c.) 14 days after 6-hydroxydopamine lesions and was expressed by challenge with SKF 38393 (3 mg/kg s.c.). In the induction phase of priming, administration of MK 801 (0.1 mg/kg s.c.) potentiated contralateral turning but differentially influenced stimulation of Fos expression in the caudate-putamen by apomorphine and by SKF 38393. Thus, MK 801 reduced in the expression phase of priming the stimulation of Fos expression by apomorphine in the dorsolateral caudate-putamen, but did not affect that by SKF 38393. MK 801, while preventing priming of SKF 38393-induced turning by apomorphine, failed to affect priming by SKF 38393. MK 801, given with apomorphine in the induction phase, reduced the stimulation of Fos expression in the dorsolateral caudate-putamen by SKF 38393. No such inhibitory effect of MK 801 on SKF38393-stimulated Fos expression was observed in rats primed with SKF 38393. These results are consistent with the possibility that MK 801 disrupts sensitization of D-1 transduction by reducing the activation of c-fos by the DA agonist during the induction phase of priming.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:03:13