Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF DIGITALIS ON CONDUCTION DYSFUNCTION IN PELIZAEUS-MERZBACHERDISEASE
Autore:
NEZU A; KIMURA S; OSAKA H; KOBAYASHI T; OHTSUKI N;
Indirizzi:
YOKOHAMA CITY UNIV,URAFUNE HOSP,DEPT PEDIAT,MINAMI KU,3-46 URAFUNE CHO YOKOHAMA KANAGAWA 232 JAPAN
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1-2, volume: 141, anno: 1996,
pagine: 49 - 53
SICI:
0022-510X(1996)141:1-2<49:EODOCD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; DEMYELINATED AXONS; MULTIPLE-SCLEROSIS; SODIUM-CHANNELS; 4-AMINOPYRIDINE; EXCITABILITY;
Keywords:
PELIZAEUS-MERZBACHER DISEASE; CONDUCTION SLOWING; RATE-DEPENDENT CONDUCTION BLOCK; DIGITALIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A. Nezu et al., "EFFECT OF DIGITALIS ON CONDUCTION DYSFUNCTION IN PELIZAEUS-MERZBACHERDISEASE", Journal of the neurological sciences, 141(1-2), 1996, pp. 49-53

Abstract

We studied the effect of digitalis on nerve conduction dysfunction inPelizaeus-Merzbacher disease (PMD). The patients were three Japanese boys with PMD, aged 7-10 years. Digitalis was administered orally in adaily dose of 0.06 mg/kg for 2 consecutive months, and the obtained serum concentrations ranged from 0.33 to 0.55 ng/ml. The digitalis therapy induced slight improvement of severe dysarthria and cognitive dysfunction in the two older patients. Electrophysiological examinations revealed the following results: In brainstem auditory evoked potentials(BAEPs), while waves II (or III) to V were absent before treatment, on treatment all waves of BAEPs except a wave IV were restored in all patients. While visual evoked potentials (VEPs) in response to transient flash stimulation showed markedly prolonged latencies before treatment, digitalis produced a mild, although not statistically significant,shortening of the latency of N160. There were also no significant changes in inter-peak amplitudes of VEPs. Transcranial cortical magnetic stimulation continued to fail to elicit motor evoked potentials of thefirst dorsal interosseous muscles in all patients. Thus, although theserum concentrations were insufficient to elicit favorable therapeutic effects, digitalis therapy provided slight relief of clinical symptoms with evidence of improvement of conduction dysfunction. It is suggested that patients with PMD may respond to symptomatic treatment modulating nerve conduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:22:29