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Titolo:
A NEW NITRIC-OXIDE DONOR, NOC-18, EXHIBITS A NOCICEPTIVE EFFECT IN THE RAT FORMALIN MODEL
Autore:
SHIBUTA S; MASHIMO T; ZHANG P; OHARA A; YOSHIYA I;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT ANAESTHESIOL,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1-2, volume: 141, anno: 1996,
pagine: 1 - 5
SICI:
0022-510X(1996)141:1-2<1:ANNDNE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; SOLUBLE GUANYLATE-CYCLASE; L-ARGININE; NERVOUS-SYSTEM; ANTINOCICEPTIVE ACTIVITY; INTERCELLULAR MESSENGER; TRANSDUCTION MECHANISM; RETROGRADE MESSENGER; POSSIBLE INVOLVEMENT; NEURONAL MESSENGER;
Keywords:
NITRIC OXIDE; NO-RELEASING COMPOUNDS; NOC-18; METHYLENE BLUE; NOCICEPTION; FORMALIN PAIN MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
S. Shibuta et al., "A NEW NITRIC-OXIDE DONOR, NOC-18, EXHIBITS A NOCICEPTIVE EFFECT IN THE RAT FORMALIN MODEL", Journal of the neurological sciences, 141(1-2), 1996, pp. 1-5

Abstract

The utility of a new nitric oxide (NO) donor, NOC-18, and the contribution of the neurotransmitter NO to nociception in response to tissue injury in rats, were examined following the subcutaneous injection of formalin into the hindpaw. This model induces biphasic responses in pain-related behavior, such that C-fiber activation during the first phase triggers a state of central sensitization characterized by the second phase. Formalin-induced nociceptive behavior was facilitated by intracerebroventricular administration of NOC-18 in the second phase, butnot the first phase. This enhancement was completely abolished by thesoluble guanylate cyclase inhibitor, methylene blue. These findings indicate that NO causes nociception via the NO-cGMP pathway in the central nervous system and NOC-18 proved to be a convenient and useful tool for the investigation of nociception-related NO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 07:58:08