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Titolo:
BACILLUS-CALMETTE-GUERIN PLUS INTRAVESICAL INTERFERON-ALPHA-2B IN PATIENTS WITH SUPERFICIAL BLADDER-CANCER
Autore:
STRICKER P; PRYOR K; NICHOLSON T; GOLDSTEIN D; GOLOVSKY D; FERGUSON R; NASH P; EHSMAN S; RUMMA J; MAMMEN G; PENNY R;
Indirizzi:
ST VINCENTS HOSP,DEPT UROL,438 VICTORIA ST SYDNEY NSW 2010 AUSTRALIA ST VINCENTS HOSP,CTR IMMUNOL SYDNEY NSW 2010 AUSTRALIA UNIV NEW S WALES SYDNEY NSW AUSTRALIA SCHERING PLOUGH PTY LTD SYDNEY NSW AUSTRALIA
Titolo Testata:
Urology
fascicolo: 6, volume: 48, anno: 1996,
pagine: 957 - 961
SICI:
0090-4295(1996)48:6<957:BPIIIP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOMA INSITU; BCG IMMUNOTHERAPY; DOSE REDUCTION; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P. Stricker et al., "BACILLUS-CALMETTE-GUERIN PLUS INTRAVESICAL INTERFERON-ALPHA-2B IN PATIENTS WITH SUPERFICIAL BLADDER-CANCER", Urology, 48(6), 1996, pp. 957-961

Abstract

Objectives. Bacillus Calmette-Guerin (BCG) and interferon alpha-ab (1FN alpha 2b) have been used individually for the treatment of bladder cancer. We used a low dose of BCG combined with IFN alpha 2b to determine the safety and to assess the efficacy of this combination therapy. Methods. A study of 12 patients with superficial bladder cancer evaluated the safety and efficacy of a combination of low-dose BCC and IFN alpha 2b, given weekly for 6 weeks. Three patients were assigned to each of four groups in which 60 mg of BCG was combined with 10, 30, 60, or 100 x 10(6) IU Of IFN alpha 2b. Results. The combination BCC/IFN alpha 2b therapy was well tolerated, with adverse effects being mild to moderate and resolved at the end of treatment. At 12 months post-treatment there has been no tumor progression. Two patients with previous multifocal transitional cell carcinoma have had solitary recurrences. One patient has had recurrent carcinoma in situ. Conclusions. This preliminary study found combination BCG/IFN alpha 2b induction therapy to be safe and well tolerated. These early results show a high response rate, but efficacy can only be determined with Phase II and III studies. Copyright 1996 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:06:17