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Titolo:
SHERPA BRAIN GLUCOSE-METABOLISM AND DEFENSE ADAPTATIONS AGAINST CHRONIC HYPOXIA
Autore:
HOCHACHKA PW; CLARK CM; MONGE C; STANLEY C; BROWN WD; STONE CK; NICKLES RJ; HOLDEN JE;
Indirizzi:
UNIV BRITISH COLUMBIA,DEPT ZOOL,6270 UNIV BLVD VANCOUVER BC V6T 1Z4 CANADA UNIV BRITISH COLUMBIA,DEPT PSYCHIAT VANCOUVER BC V6T 1Z4 CANADA UNIV BRITISH COLUMBIA,SPORTS MED DIV VANCOUVER BC V6T 1Z4 CANADA UNIV PERUANA CAYETANO HEREDIA,DEPT PHYSIOL LIMA 100 PERU UNIV WISCONSIN,DEPT MED PHYS RADIOL & MED MADISON WI 53706
Titolo Testata:
Journal of applied physiology
fascicolo: 3, volume: 81, anno: 1996,
pagine: 1355 - 1361
SICI:
8750-7587(1996)81:3<1355:SBGADA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-ALTITUDE; ANDEAN NATIVES; HYPOBARIC HYPOXIA; PLASMA-GLUCOSE; MUSCLE; DEPENDENCE; CAPACITY; RATS;
Keywords:
HYPOXIA ADAPTATION; POSITRON-EMISSION TOMOGRAPHY; QUECHUA; ALTITUDE ADAPTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
P.W. Hochachka et al., "SHERPA BRAIN GLUCOSE-METABOLISM AND DEFENSE ADAPTATIONS AGAINST CHRONIC HYPOXIA", Journal of applied physiology, 81(3), 1996, pp. 1355-1361

Abstract

The brain of hypoxia-tolerant vertebrates is known to survive extremeoxygen limitation at least in part because of very low rates of ATP utilization and ATP production. To assess whether similar adaptations are involved in healthy humans during hypoxia adaptations over generational time, we initially used positron-emission tomography measurementsof glucose metabolic rates in the brain of Quechuas, whose ancestors have been indigenous to the Andes at altitudes between similar to 3,300 and 4,500 m for several hundred years, Workers in this field generally believe that the lineage of Sherpas has been indigenous to the Himalayas for even longer and that Sherpas and other peoples indigenous tothe Tibetan plateau are perhaps the most exquisitely hypoxia adapted of all humans. For this reason, in this study we extended our databaseto include Sherpas. With the use of the same protocols as before, twometabolic states were analyzed: I)the presumed normal (hypoxia-adapted) state, monitored as soon as possible after subjects left the Himalayas and 2) the deacclimated state, monitored after 3 wk at low altitudes. Positron-emission tomography measurements of 2-[F-18]deoxy-2-fluoro-D-glucose metabolic rates, quantified in 26 regions of the brain, indicated that the Sherpas' brain metabolism differed significantly fromthat of Quechuas but was essentially identical to that of lowlanders. Region-by-region patterns were similar in all three groups, indicating that the regional organization of glucose metabolism in the brain isa conservative, relatively constant characteristic.

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Documento generato il 30/03/20 alle ore 13:31:33