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Titolo:
INFLUENCE OF A POTENTIAL ANTIASTHMATIC DRUG, CR-2039, UPON THE ANTICONVULSIVE ACTIVITY OF CONVENTIONAL ANTIEPILEPTICS AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE
Autore:
CZUCZWAR SJ; GASIOR M; KOZICKA M; PIETRASIEWICZ T; TURSKI WA; KLEINROK Z;
Indirizzi:
LUBLIN MED UNIV SCH,DEPT PHARMACOL & TOXICOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND LUBLIN MED UNIV SCH,DEPT PHARMACOL PL-20090 LUBLIN POLAND
Titolo Testata:
Journal of neural transmission
fascicolo: 12, volume: 103, anno: 1996,
pagine: 1371 - 1379
SICI:
0300-9564(1996)103:12<1371:IOAPAD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTECTIVE ACTIVITY; ANTIELECTROSHOCK ACTIVITY; CHRONIC AMINOPHYLLINE; INDUCED CONVULSIONS; ELECTROCONVULSIONS; VALPROATE; DIPHENYLHYDANTOIN; ENPROFYLLINE; ANTAGONISTS; DIAZEPAM;
Keywords:
ANTIEPILEPTICS; CR 2039; SEIZURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Czuczwar et al., "INFLUENCE OF A POTENTIAL ANTIASTHMATIC DRUG, CR-2039, UPON THE ANTICONVULSIVE ACTIVITY OF CONVENTIONAL ANTIEPILEPTICS AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE", Journal of neural transmission, 103(12), 1996, pp. 1371-1379

Abstract

CR 2039 ol-5-yl)-N-(4-(1H-tetrazol-5-yl]phenyl-benzamide], in doses of 10, 50, and 100mg/kg i.p., significantly elevated the threshold for electroconvulsions, increasing the CS50 (current strength 50% in mA) values from 6.3 to 7.2, 7.5, and 7.6 mA, respectively. When combined with carbamazepine, diphenylhydantoin, or valproate, CR 2039 (5 and 10 mg/kg) potentiated the anticonvulsive action of these antiepileptics against maximal electroshock-induced convulsions which was reflected by significant decreases in the respective ED(50)s (in mg/kg). The protective efficacy of phenobarbital was not affected by the phenylbenzamidederivative. The potentiation of the anticonvulsive activity of three antiepileptics was not accompanied by increased adverse effects, evaluated in the chimney test (motor coordination) and passive avoidance task (long-term memory). Finally, CR 2039 (10 mg/kg) did not alter the plasma levels of the antiepileptic drugs studied which speaks against apharmacokinetic mechanism in the observed results. It is concluded that CR 2039 may prove a safer anti-asthmatic drug for the use in epileptic patients than aminophylline which, either acutely or chronically, considerably impaired the anticonvulsive activity of conventional antiepileptics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:31:41