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Titolo:
REGIONAL DISTRIBUTION OF A CREATINE TRANSPORTER IN RAT AUDITORY BRAIN-STEM - AN IN-SITU HYBRIDIZATION STUDY
Autore:
HIEL H; HAPPE HK; WARR WB; MORLEY BJ;
Indirizzi:
BOYS TOWN NATL RES HOSP,NEUROCHEM LAB,555 N 30TH ST OMAHA NE 68131 BOYS TOWN NATL RES HOSP,NEUROCHEM LAB OMAHA NE 68131
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 98, anno: 1996,
pagine: 29 - 37
SICI:
0378-5955(1996)98:1-2<29:RDOACT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL EXPRESSION; INFERIOR COLLICULUS; KINASE ISOENZYMES; NERVOUS-SYSTEM; MUSCLE; CLONING; TISSUES; CDNA; FAMILY; ENERGY;
Keywords:
CREATINE TRANSPORTER; IN-SITU HYBRIDIZATION; CENTRAL AUDITORY SYSTEM; HIGH-ENERGY PHOSPHATE METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
H. Hiel et al., "REGIONAL DISTRIBUTION OF A CREATINE TRANSPORTER IN RAT AUDITORY BRAIN-STEM - AN IN-SITU HYBRIDIZATION STUDY", Hearing research, 98(1-2), 1996, pp. 29-37

Abstract

The expression of an mRNA encoding a creatine transporter (CRT1) was investigated in the rat auditory system under ambient sound conditions, using radiolabeled and non-radiolabeled oligonucleotide in-situ hybridization. The results indicated that CRT1 mRNA is widely distributed in auditory nuclei, including the fusiform and deep layers of the dorsal cochlear nucleus, the ventral cochlear nucleus, the superior olivary complex, the nuclei of the lateral lemniscus and the inferior colliculus. The molecular layer of the dorsal cochlear nucleus and the medial geniculate have low levels of label. Creatine provides cells with a reservoir of high-energy phosphate. Neurons do not synthesize creatinebut accumulate it by a transport mechanism, which is probably the limiting step in the regulation of intracellular creatine. Therefore, thequantity of transporter expressed may reflect the utilization of creatine and could serve as an in-vitro indicator of endogenous high-energy metabolism in some cells. Although most auditory nuclei express CRT1mRNA, the quantity of CRT1 mRNA varies among auditory nuclei, indicating that many auditory nuclei have high and fluctuating energy requirements. The level of CRT1 transcript or protein may be regulated by chronic metabolic changes in the auditory system that may occur, for example, with damage to the acoustic organ or the aging process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 23:57:27