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Titolo:
MULTICENTRIC EPITHELIOID ANGIOSARCOMA OF THE BONE - PITFALLS IN CLINICAL AND MORPHOLOGICAL DIAGNOSIS
Autore:
BALICKI D; BUHRMANN R; MACLEAN J; COOPER B; MINASSIAN H; WANG NS; HUTTNER I;
Indirizzi:
MCGILL UNIV,DEPT PATHOL,LYMAN DUFF MED SCI BLDG,3775 UNIV ST MONTREALPQ H3A 2B4 CANADA MCGILL UNIV,DEPT PATHOL MONTREAL PQ H3A 2B4 CANADA MCGILL UNIV,DEPT MED MONTREAL PQ H3A 2B4 CANADA
Titolo Testata:
Blood cells, molecules, & diseases
fascicolo: 17, volume: 22, anno: 1996,
pagine: 205 - 213
SICI:
1079-9796(1996)22:17<205:MEAOTB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOKERATIN EXPRESSION; SOFT-TISSUE; HEMANGIOENDOTHELIOMA; NEOPLASMS; MISTAKEN; TUMORS; GLAND;
Keywords:
BONE; ANGIOSARCOMA; EPITHELIOID ANGIOSARCOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
D. Balicki et al., "MULTICENTRIC EPITHELIOID ANGIOSARCOMA OF THE BONE - PITFALLS IN CLINICAL AND MORPHOLOGICAL DIAGNOSIS", Blood cells, molecules, & diseases, 22(17), 1996, pp. 205-213

Abstract

Epithelioid angiosarcoma of the bone represents a challenging diagnosis by bone marrow biopsy. We present a case of a multicentric high grade angiosarcoma of the bone with epithelioid features. On the basis ofthe clinical presentation, the radiological findings, and the appearance of loosely clustered tumor cells detected in the initial bone marrow biopsy, the main differential diagnoses considered were a poorly differentiated nonsecretory multiple myeloma and metastatic carcinoma. Subsequent morphologic, immunohistochemical and electron microscopic examination of tissue samples clarified the nature of the tumor as epithelioid angiosarcoma. We discuss potential pitfalls in clinical and morphological diagnosis. The strong reactivity of the tumor cells with the nonspecific but ubiquitous mesenchymal marker vimentin in similar cases should direct early attention to the rare malignant bone tumor, epithelioid angiosarcoma, with subsequent confirmation of this diagnosiswith specific immunohistochemical endothelial cell markers and/or electron microscopy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:23:08