Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DISCORDANT EFFECTS OF GUANIDINES ON RENAL STRUCTURE AND FUNCTION AND ON REGIONAL VASCULAR DYSFUNCTION AND COLLAGEN CHANGES IN DIABETIC RATS
Autore:
NYENGAARD JR; CHANG K; BERHORST S; REISER KM; WILLIAMSON JR; TILTON RG;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,BOX 8118,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PATHOL ST LOUIS MO 63110 AARHUS UNIV,STEREOL RES LAB DK-8000 AARHUS DENMARK UNIV CALIF DAVIS,SCH MED,DEPT MED DAVIS CA 95616 TEXAS BIOTECHNOL CORP,DEPT CELLULAR BIOL HOUSTON TX 00000
Titolo Testata:
Diabetes
fascicolo: 1, volume: 46, anno: 1997,
pagine: 94 - 106
SICI:
0012-1797(1997)46:1<94:DEOGOR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; GLYCOSYLATION END-PRODUCTS; GLOMERULAR-BASEMENT-MEMBRANE; ALDOSE REDUCTASE INHIBITION; INTRACELLULAR FREE CALCIUM; ADVANCED GLYCATION; CROSS-LINKING; EXTRACELLULAR-MATRIX; METABOLIC IMBALANCES; LINKED FLUORESCENCE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
102
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Nyengaard et al., "DISCORDANT EFFECTS OF GUANIDINES ON RENAL STRUCTURE AND FUNCTION AND ON REGIONAL VASCULAR DYSFUNCTION AND COLLAGEN CHANGES IN DIABETIC RATS", Diabetes, 46(1), 1997, pp. 94-106

Abstract

We examined the effects of aminoguanidine and methylguanidine on vascular dysfunction, glomerular structural changes, and indexes of early and late nonenzymatic glycation in 7-month streptozotocin-induced diabetic rats. Kidney weight, glomerular volume, fractional mesangial volume, glomerular capillary basement membrane width, and urinary albumin excretion were increased in diabetic rats. Diabetes also 1) increased vascular albumin permeation twofold in retina, sciatic nerve, aorta, skin, and kidney; 2) decreased renal collagenase-soluble collagen; 3) increased collages-associated fluorescence in kidney and skin but not in aorta; and 4) increased glycated hemoglobin levels and aortic pentosidine levels. Aminoguanidine reduced albuminuria by 70% after 4 months, and both guanidines 1) normalized aortic pentosidine levels and renal collagenase-soluble collagen, 2) had no effect on glycated hemoglobin levels or collagen-associated fluorescence (in aorta, kidney, or skin), and 3) had little or no effect on regional albumin permeation. These discordant effects of aminoguanidine on diabetes-induced vascular changes versus parameters of nonenzymatic glycation are consistent witha multifactorial pathogenesis of diabetic complications, including roles for metabolic imbalances independent of nonenzymatic glycation. Tothe extent that glomerular matrix accumulation and increased regionalalbumin permeation in chronically diabetic rats are sequelae of nonenzymatic glycation, these findings point to an important role for earlyglycation reactions and products.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:43:00