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Titolo:
INSULIN SENSITIVITY AND ACUTE INSULIN-RESPONSE IN AFRICAN-AMERICANS, NON-HISPANIC WHITES, AND HISPANICS WITH NIDDM - THE INSULIN-RESISTANCEATHEROSCLEROSIS STUDY
Autore:
HAFFNER SM; HOWARD G; MAYER E; BERGMAN RN; SAVAGE PJ; REWERS M; MYKKANEN L; KARTER AJ; HAMMAN R; SAAD MF;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT MED,7703 FLOUD CURL DR SAN ANTONIO TX 78284 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS LOS ANGELES CA 90033 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,NIH BETHESDA MD 20892 UNIV COLORADO,SCH MED,DEPT PREVENT MED & BIOMETR DENVER CO 00000 UNIV KUOPIO,DEPT MED FIN-70211 KUOPIO FINLAND KAISER PERMANENTE,DIV RES OAKLAND CA 00000 UNIV SO CALIF,SCH MED,DEPT MED LOS ANGELES CA 90033
Titolo Testata:
Diabetes
fascicolo: 1, volume: 46, anno: 1997,
pagine: 63 - 69
SICI:
0012-1797(1997)46:1<63:ISAAII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; BODY-FAT DISTRIBUTION; GLUCOSE-TOLERANCE TEST; MEXICAN-AMERICANS; MINIMAL MODEL; ADIPOSE-TISSUE; BLACK; OBESITY; RISK; KETOACIDOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Haffner et al., "INSULIN SENSITIVITY AND ACUTE INSULIN-RESPONSE IN AFRICAN-AMERICANS, NON-HISPANIC WHITES, AND HISPANICS WITH NIDDM - THE INSULIN-RESISTANCEATHEROSCLEROSIS STUDY", Diabetes, 46(1), 1997, pp. 63-69

Abstract

NIDDM is usually characterized by beta-cell failure and decreased insulin sensitivity, It has been reported that a high proportion of African-American NIDDM subjects are insulin sensitive, To examine this issue, we determined insulin sensitivity (S-1) in 479 NIDDM subjects by minimal model analyses of frequently sampled intravenous glucose tolerance (FSIGT) from the Insulin Resistance Atherosclerosis Study (IRAS), alarge multicenter study of insulin sensitivity and cardiovascular risk in African-Americans, Hispanics, and non-Hispanic whites, The African-Americans and non-Hispanic whites were sampled in Los Angeles and Oakland, California, The non-Hispanic whites and Hispanics were sampled in San Antonio, Texas, and San Luis Valley, Colorado, We defined the proportion of insulin-sensitive (S-1) subjects as greater than or equalto 1.61 min(-1) . pU(-1) . ml(-1), which is above the median for nondiabetic subjects of all ethnic groups in the IRAS, Using this definition, the proportion of insulin-sensitive diabetic subjects was very lowin all ethnic groups (non-Hispanic whites [14.3%] vs, African-Americans [6.5%], P = 0.039 in Los Angeles and Oakland; non-Hispanic whites [6.8%] vs, Hispanics [4.9%], P = 0.737 in San Luis Valley and San Antonio). These results were also similar in newly diagnosed mildly hyperglycemic diabetic subjects. In addition, these results were not affectedby the adjustment for differences in obesity, body fat distribution, and severity of hyperglycemia. Even in nonobese subjects (with BMI <30kg/m(2)), the proportion of insulin-sensitive subjects (S-1 greater than or equal to 1.61 min(-1) . mu U-1 . ml(-1)) was low (3.6-9.7%). The acute insulin response (AIR) was significantly higher in African-Americans than in non-Hispanic whites; there were no ethnic differences in AIR between Hispanics and non-Hispanic whites, There were no significant ethnic differences for non-insulin-mediated glucose disposal (S-G). We conclude that the number of insulin-sensitive NIDDM subjects is low and similar among non-Hispanic whites, Hispanics, and African-Americans in the U.S.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:00:01