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Titolo:
IMMUNOHISTOCHEMICAL EXAMINATION OF PHOSPHORYLATED TAU IN GRANULOVACUOLAR DEGENERATION GRANULES
Autore:
IKEGAMI K; KIMURA T; KATSURAGI S; ONO T; YAMAMOTO H; MIYAMOTO E; MIYAKAWA T;
Indirizzi:
NATL KIKUCHI HOSP,DIV CLIN RES,208 KOSHI MACHI KUMAMOTO 86111 JAPAN KUMAMOTO UNIV,SCH MED,DEPT NEUROPSYCHIAT KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,DEPT PHARMACOL KUMAMOTO 860 JAPAN
Titolo Testata:
PSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 3, volume: 50, anno: 1996,
pagine: 137 - 140
SICI:
1323-1316(1996)50:3<137:IEOPTI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; HIPPOCAMPAL CORTEX; DEMENTED PATIENTS; PHF-TAU; PROTEIN; NEUROFILAMENTS; SEQUESTRATION; LOCALIZATION; ANTIBODIES;
Keywords:
GRANULOVACUOLAR DEGENERATION; NEUROFIBRILLARY TANGLE; PAIRED HELICAL FILAMENT; PHOSPHORYLATED TAU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
K. Ikegami et al., "IMMUNOHISTOCHEMICAL EXAMINATION OF PHOSPHORYLATED TAU IN GRANULOVACUOLAR DEGENERATION GRANULES", PSYCHIATRY AND CLINICAL NEUROSCIENCES, 50(3), 1996, pp. 137-140

Abstract

Granulovacuolar degeneration (GVD) and neurofibrillary tangles (NFT) are neuropathological features in Alzheimer's disease (AD). The molecular mechanism of GVD formation remains unknown. Recent immunohistochemical investigations suggested a potential link of NFT to GVD formation. Enzyme histochemical studies and electronmicroscopic findings suggested that GVD is formed through lysosomal autophagy of intraneuronal substances. We recently demonstrated that in non-demented cases NFT was phosphorylated at serines 199, 202 and 422 in paired helical filament (PHF)-tau more than in serine 396, while NFT in AD cases was similarlyphosphorylated at these four sites in tau. In this study, we demonstrated immunohistochemically a similar phosphorylation state of tau in GVD granules to that in NFT in both non-demented cases and AD patients by using a mouse monoclonal anti-tau antibody and three phosphorylation site-specific antibodies for PHF-tau, indicating that GVD granules and NFT are composed of similar phosphorylated-tau. However, we could not detect PHF structures within ally GVD using electronmicroscopy, indicating that PHF itself is not phagocytized by lysosomes during GVD formation. Therefore, the source of GVD granules might be phosphorylatedpre-PHF-tau.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:27:57