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Titolo:
MONOCYTOID MARGINAL ZONE B-CELL DIFFERENTIATION IN FOLLICLE CENTER CELL LYMPHOMA/
Autore:
SCHMID U; COGLIATTI SB; DISS TC; ISAACSON PG;
Indirizzi:
KANTONSSPITAL,DEPT PATHOL CH-9007 ST GALLEN SWITZERLAND KANTONSSPITAL,DEPT PATHOL CH-9007 ST GALLEN SWITZERLAND UNIV COLL LONDON,SCH MED,DEPT HISTOPATHOL LONDON W1N 8AA ENGLAND
Titolo Testata:
Histopathology
fascicolo: 3, volume: 29, anno: 1996,
pagine: 201 - 208
SICI:
0309-0167(1996)29:3<201:MMZBDI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMATURE SINUS HISTIOCYTES; MARGINAL ZONE; MONOCLONAL-ANTIBODIES; HODGKINS-DISEASE; LYMPHOCYTES-B; T(14-18); TISSUE; HISTOGENESIS; COLONIZATION; POPULATION;
Keywords:
MONOCYTOID B-CELL LYMPHOMA; MONOCYTOID MARGINAL ZONE B-CELL DIFFERENTIATION; FOLLICLE CENTER CELL LYMPHOMA; GENE REARRANGEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
U. Schmid et al., "MONOCYTOID MARGINAL ZONE B-CELL DIFFERENTIATION IN FOLLICLE CENTER CELL LYMPHOMA/", Histopathology, 29(3), 1996, pp. 201-208

Abstract

We report on two cases of low grade follicle centre cell lymphoma with a pronounced parafollicular monocytoid/ marginal zone B-cell component. One patient had a history of preceeding follicular high grade B-cell lymphoma of centroblastic type showing the same light chain restriction and identical immunoglobulin heavy chain gene rearrangement as the low grade lymphoma diagnosed 15 months later, Morphologically, in both cases the two constituents of the low grade tumours were clearly distinguishable. Immunohistochemically, the follicular component strongly expressed bcl-2 protein in contrast to a weak staining of the marginal zone B-cell component. Performing PCR, a rearrangement of the majorbreakpoint region of bcl-2 was not found. Identical light chain restriction of the follicular and the monocytoid B-cell/marginal zone components strongly indicates a clonal relationship between them, A monocytoid/marginal zone B-cell component in follicular lymphoma probably results from differentiation of the follicle centre cells and does not indicate a composite lymphoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:14:31