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Titolo:
NORMAL SERUM INDEXES OF BONE-COLLAGEN BIOSYNTHESIS AND DEGRADATION INSMALL-FOR-GESTATIONAL-AGE INFANTS
Autore:
NAMGUNG R; TSANG RC; SIERRA RI; HO ML;
Indirizzi:
YONSEI UNIV,COLL MED,DEPT PEDIAT,SUNDAEMOON KU,134 SHINCHON DONG SEOUL SOUTH KOREA UNIV CINCINNATI,COLL MED,CHILDRENS HOSP RES FDN,PEDIAT BONE RES CTR,DEPT PEDIAT,DIV NEONATOL CINCINNATI OH 45267
Titolo Testata:
Journal of pediatric gastroenterology and nutrition
fascicolo: 3, volume: 23, anno: 1996,
pagine: 224 - 228
SICI:
0277-2116(1996)23:3<224:NSIOBB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH FACTOR-I; BINDING-PROTEINS; NEWBORN-INFANTS; MINERAL CONTENT; FORMATION RATES; PAGETS-DISEASE; FETAL RATS; INSULIN; PROCOLLAGEN; SOMATOMEDIN;
Keywords:
SGA INFANTS; BONE COLLAGEN TYPE I; CALCIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R. Namgung et al., "NORMAL SERUM INDEXES OF BONE-COLLAGEN BIOSYNTHESIS AND DEGRADATION INSMALL-FOR-GESTATIONAL-AGE INFANTS", Journal of pediatric gastroenterology and nutrition, 23(3), 1996, pp. 224-228

Abstract

Serum carboxyterminal propeptide of type I procollagen (PICP) and cross-linked carboxyterminal telopeptide of type I collagen (ICTP), new markers of bone collagen type I biosynthesis and degradation, have not been studied in small for gestational age (SGA) infants. In an earlierstudy, we found a lower bone mineral content (BMC) and decreased serum osteocalcin in SGA than in appropriate for gestational age (AGA) infants, supporting the thesis that decreased fetal bone formation is a cause of lower BMC in SGA. In view of the role of insulin-like growth factor-I (IGF-I) in the regulation of collagen type I synthesis and degradation, and low serum IGF-I concentrations in SCA infants, we hypothesized that serum PICP would be lower and serum ICTP would be higher in SGA than in AGA infants, reflecting decreased bone collagen type I biosynthesis or enhancement of bone collagen type I degradation in SGA. We studied 19 term SGA and 38 term AGA infants that were matched specifically 1:2 by gestation and birth month. There were no differences between SGA and AGA infants in serum PICP nor ICTP concentrations. Serum ICTP was correlated with osteocalcin and with PICP in SGA infants but not in AGA infants. Thus, serum biochemical indices of bone collagentype I biosynthesis and degradation in term SGA infants are similar to those in term AGA infants. These findings are not consistent with the thesis of altered fetal bone collagen type I biosynthesis or degradation in SGA. We suggest that the reduced bone mineral content in SGA infants is predominantly related to a lower supply of minerals rather than defective regulation of bone collagen type I metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:51:54