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Titolo:
LOCATING REWARD CUE AT RESPONSE MANIPULANDUM (CAM) INDUCES SYMPTOMS OF DRUG-ABUSE
Autore:
TOMIE A;
Indirizzi:
RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08903
Titolo Testata:
Neuroscience and biobehavioral reviews
fascicolo: 3, volume: 20, anno: 1996,
pagine: 505 - 535
SICI:
0149-7634(1996)20:3<505:LRCARM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE-RATIO SCHEDULE; FREELY-MOVING RATS; SELF-ADMINISTRATION BEHAVIOR; INDUCED LOCOMOTOR-ACTIVITY; VENTRAL TEGMENTAL AREA; INCREASE EXTRACELLULAR DOPAMINE; METHADONE-MAINTENANCE TREATMENT; PIMOZIDE BLOCKS ESTABLISHMENT; PSYCHOMOTOR STIMULANT-DRUGS; MEDIAL PREFRONTAL CORTEX;
Keywords:
DISCRIMINATIVE STIMULUS; RESPONSE MANIPULANDUM; INSTRUMENTAL DISCRIMINATION LEARNING; AUTOSHAPING; DRUG ABUSE; DRUG SELF-ADMINISTRATION; DRUG-TAKING IMPLEMENT; DOPAMINE; INCENTIVE-MOTIVATION; PSYCHOMOTOR ACTIVATION; SENSITIZATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
575
Recensione:
Indirizzi per estratti:
Citazione:
A. Tomie, "LOCATING REWARD CUE AT RESPONSE MANIPULANDUM (CAM) INDUCES SYMPTOMS OF DRUG-ABUSE", Neuroscience and biobehavioral reviews, 20(3), 1996, pp. 505-535

Abstract

Appetitive instrumental discrimination learning procedures provide for CAM (cue and manipulandum) when the reward cue (discriminative stimulus positively correlated with positive reinforcement) is located at the response manipulandum (object that when contacted or manipulated defines the performance of the instrumental response). Evidence reviewedshows that CAM induces excessive and compulsive instrumental responding relative to otherwise comparable non-CAM control procedures. In humans, symptoms of drug abuse are particularly likely when the drug-taking implement (response manipulandum at which instrumental drug-taking is directed) is also predictive of the drug's rewarding effects (reward cue). Evidence that the predictive relationship between a drug-taking implement and drug reward relates to drug abuse is reviewed, and implications for treatment and prevention are considered. CAM is related to neurobiological models of drug abuse that emphasize the role of theneurotransmitter dopamine (DA). CAM produces convergence of DA-mediated responding for conditioned reinforcement with DA mediation of psychomotor activation and incentive-motivational processes to yield reflexive cue-directed responding not observed in non-CAM controls. Copyright (C) 1996 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:10:34