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Titolo:
TRANSFORMING GROWTH-FACTOR-BETA IN BOVINE PLACENTAS
Autore:
MUNSON L; WILHITE A; BOLTZ VF; WILKINSON JE;
Indirizzi:
UNIV TENNESSEE,COLL VET MED,DEPT PATHOL KNOXVILLE TN 37901 SMITHSONIAN INST,NATL ZOOL PK,DEPT PATHOL WASHINGTON DC 20008
Titolo Testata:
Biology of reproduction
fascicolo: 4, volume: 55, anno: 1996,
pagine: 748 - 755
SICI:
0006-3363(1996)55:4<748:TGIBP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TGF-BETA; LOCALIZATION; ENDOMETRIAL; EXPRESSION; ISOFORMS; RECEPTOR; CELLS; FACTOR-BETA-1; TGF-BETA-1; SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
L. Munson et al., "TRANSFORMING GROWTH-FACTOR-BETA IN BOVINE PLACENTAS", Biology of reproduction, 55(4), 1996, pp. 748-755

Abstract

Transforming growth factor beta s (TGF beta) are a family of multifunctional growth factors that are important embryonic morphogens. Because TGF beta s may regulate the development of epitheliochorial placentas, we investigated the location, expression, secretion, and effects ofTGF beta s in bovine placentomes and cell cultures derived from chorionic and endometrial epithelia. Placentomes from early second-trimester pregnancies were examined by immunohistochemistry for TGF beta 1, TGF beta 2, and TGF beta 3, and for TGF beta expression in Northern slot-blots. Effects of TGF beta s were assessed in trophoblastic and endometrial epithelial cell lines by DNA synthesis assays. Secretion of TGFbeta s by trophoblastic and endometrial epithelial cells was determined using bioassays. All forms of TGF beta were immunolocalized in bovine placentomes. TGF beta mRNA was expressed in chorioallantois, caruncles, and in cultured trophoblastic and endometrial epithelial cells. Endometrial and trophoblastic cells secreted active and latent TGF betas, and these cells had a transient proliferative response to all forms of TGF beta. These results indicate that TGF beta are present at thefetal-maternal interface of the bovine placentome and may promote endometrial and chorionic growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:35:37