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Titolo:
IMMUNOGENETICS OF HTLV-I II AND ASSOCIATED DISEASES/
Autore:
SONODA S; FUJIYOSHI T; YASHIKI S;
Indirizzi:
KAGOSHIMA UNIV,FAC MED,DEPT VIROL,8-35-1 SAKURAGAOKA KAGOSHIMA 890 JAPAN
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
, volume: 13, anno: 1996, supplemento:, 1
pagine: 119 - 123
SICI:
1077-9450(1996)13:<119:IOHIAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROPICAL SPASTIC PARAPARESIS; CYTOTOXIC LYMPHOCYTES-T; I PX; VIRUS; CARRIERS; CELLS; GENE;
Keywords:
HUMAN T-LYMPHOTROPIC VIRUS TYPES I AND II (HTLV-I/II); ADULT T-CELL LEUKEMIA; HTLV-I-ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS; HUMAN LEUKOCYTE ANTIGEN (HLA) ALLELES; HLA HAPLOTYPES; IMMUNE RESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S. Sonoda et al., "IMMUNOGENETICS OF HTLV-I II AND ASSOCIATED DISEASES/", Journal of acquired immune deficiency syndromes and human retrovirology, 13, 1996, pp. 119-123

Abstract

The ethnic background of human T-lymphotropic virus types I and II(HTLV-I/II) infections and associated diseases was investigated in association with human leukocyte antigens (HLA) (alleles) and haplotypes. Japanese HTLV-I carriers were characterized by two categories of HLA class I antigens (A24, A26, B7, B61, Cw1, and Cw7) and class II alleles (DRB10101, 0803, 1403, 1501, and 1502 and DQB1*0303, 0501, and 0601); one category was associated with adult T-cell leukemia (ATL) patients and the other with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. The ATL-associated haplotypes had unique DRB1-DQB1 alleles (0901-0303, 1501-0602, 1401-0503), which were correlated with a low immune responsiveness to HTLV-I, while the HAM/TSP haplotypes had different DRB1-DQB1 alleles (0101-0501, 0803-0601, 1502-0601), which were correlated with a high immune responsiveness to HTLV-I. Both ATL- and HAM/TSP-associated haplotypes were found among HTLV-I carriers and the patients from other ethnic groups (Jamaican blacks, Andes natives, South American mestizos, and Mashhadi Jews). HLA haplotypes of HTLV-II carriers were different from those of HTLV-I carriers among South American natives. These results suggested that HTLV-I/II infections and the associated diseases might be determined by immunogenetic factors segregated with HLA alleles and haplotypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 16:55:59