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Titolo:
IN-VIVO MAPPING OF CHOLINERGIC TERMINALS IN NORMAL AGING, ALZHEIMERS-DISEASE, AND PARKINSONS-DISEASE
Autore:
KUHL DE; MINOSHIMA S; FESSLER JA; FREY KA; FOSTER NL; FICARO EP; WIELAND DM; KOEPPE RA;
Indirizzi:
UNIV MICHIGAN HOSP,DIV NUCL MED,1500 E MED CTR DR,UH B1 G412-0028 ANNARBOR MI 48109 UNIV MICHIGAN,DIV NUCL MED ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT NEUROL ANN ARBOR MI 48109
Titolo Testata:
Annals of neurology
fascicolo: 3, volume: 40, anno: 1996,
pagine: 399 - 410
SICI:
0364-5134(1996)40:3<399:IMOCTI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 VESAMICOL BINDING; FUNCTIONAL BRAIN IMAGES; ACETYLTRANSFERASE ACTIVITY; SENILE DEMENTIA; BASAL FOREBRAIN; SELECTIVE LOSS; NEURONS; NUCLEUS; TOMOGRAPHY; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Kuhl et al., "IN-VIVO MAPPING OF CHOLINERGIC TERMINALS IN NORMAL AGING, ALZHEIMERS-DISEASE, AND PARKINSONS-DISEASE", Annals of neurology, 40(3), 1996, pp. 399-410

Abstract

To map presynaptic cholinergic terminal densities in normal aging (n = 36), Alzheimer's; disease (AD) (n = 22), and Parkinson's disease (PD) (n = 15), we performed single-photon emission computed tomography using [I-123]iodobenzovesamicol (IBVM), an in vivo marker of the vesicular acetylcholine transporter. We used coregistered positron emission tomography with [F-18]fluorodeoxyglucose for metabolic assessment and coregistered magnetic resonance imaging for atrophy assessment. In controls (age, 22-91 years), cortical IBVM binding declined only 3.7% per decade. In AD, cortical binding correlated inversely with dementia severity. In mild dementia, binding differed according to age of onset, but metabolism did not. With an onset age of less than 65 years, binding was reduced severely throughout the entire cerebral cortex and hippocampus (about 30%), but with an onset age of 65 years or more, bindingreductions were restricted to temporal cortex and hippocampus. In PD without dementia, binding was reduced only in parietal and occipital cortex, but demented PD subjects had extensive cortical binding decreases similar to early-onset AD. We conclude that cholinergic neuron integrity can be monitored in living AD and PD patients, and that it is not so devastated in vivo as suggested by postmortem choline acetyltransferase activity (50-80%).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:57:16