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Titolo:
MODULATORY ACTIONS OF DOPAMINE ON NMDA RECEPTOR-MEDIATED RESPONSES ARE REDUCED IN D-1A-DEFICIENT MUTANT MICE
Autore:
LEVINE MS; ALTEMUS KL; CEPEDA C; CROMWELL HC; CRAWFORD C; ARIANO MA; DRAGO J; SIBLEY DR; WESTPHAL H;
Indirizzi:
UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR,760 WESTWOOD PLAZA LOSANGELES CA 90024 FINCH UNIV HLTH SCI CHICAGO MED SCH,DEPT NEUROSCI N CHICAGO IL 60064 MONASH UNIV,DEPT ANAT CLAYTON VIC 3168 AUSTRALIA NINCDS,EXPT THERAPEUT BRANCH BETHESDA MD 20892 NICHHD,LAB MAMMALIAN GENES & DEV BETHESDA MD 20892
Titolo Testata:
The Journal of neuroscience
fascicolo: 18, volume: 16, anno: 1996,
pagine: 5870 - 5882
SICI:
0270-6474(1996)16:18<5870:MAODON>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; RAT STRIATAL NEURONS; CAT CAUDATE NEURONS; NEOSTRIATAL NEURONS; SYNAPTIC TRANSMISSION; CORTICAL INPUTS; MIXED SYNAPSES; BASAL GANGLIA; IN-VITRO; INVITRO;
Keywords:
DOPAMINE RECEPTORS; D-1; EXCITATORY AMINO ACID RECEPTORS; KNOCK-OUT MICE; MUTANT; NEOSTRIATAL SLICES; NMDA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Levine et al., "MODULATORY ACTIONS OF DOPAMINE ON NMDA RECEPTOR-MEDIATED RESPONSES ARE REDUCED IN D-1A-DEFICIENT MUTANT MICE", The Journal of neuroscience, 16(18), 1996, pp. 5870-5882

Abstract

The role of D-1 dopamine (DA) receptors in mediating the ability of DA to modulate responses attributable to activation of NMDA receptors was examined in mice lacking D-1A dopamine receptors. Specifically, experiments were designed to test the hypothesis that the ability of DA to potentiate responses mediated by activation of NMDA receptors was attributable to activation of D-1 receptors. Based on this hypothesis, we would predict that in the D-1A mutant mouse, either DA would not induce enhancement of NMDA-mediated responses, or the enhancement would be severely attenuated. The results provided evidence to support the hypothesis. In mutant mice, DA and D-1 receptor agonists did not potentiate responses mediated by activation of NMDA receptors. In contrast, in control mice, both DA and D-1 receptor agonists markedly potentiatedresponses mediated by activation of NMDA receptors. The effects of DAin attenuating responses mediated by activation of non-NMDA receptorsalso were altered in the mutant, suggesting that this action of DA may require coupling or interactions between D-1 and D-2 receptors. The present studies also provided an opportunity to assess some of the basic electrophysiological and morphological properties of neostriatal neurons in mice lacking D-1A DA receptors. Resting membrane potential, action potential parameters, input resistance, excitability, somatic size, dendritic extent, and estimates of spine density in mutants and controls were similar, suggesting that these basic neurophysiological and structural properties have not been changed by the loss of the D-1A DA receptor.

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Documento generato il 20/09/20 alle ore 19:34:07