Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INTERKINETIC AND MIGRATORY BEHAVIOR OF A COHORT OF NEOCORTICAL NEURONS ARISING IN THE EARLY EMBRYONIC MURINE CEREBRAL WALL
Autore:
TAKAHASHI T; NOWAKOWSKI RS; CAVINESS VS;
Indirizzi:
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,25 FRUIT ST BOSTON MA 02114 KEIO UNIV,SCH MED,DEPT PEDIAT TOKYO 160 JAPAN UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROSCI & CELL BIOL PISCATAWAY NJ 08854
Titolo Testata:
The Journal of neuroscience
fascicolo: 18, volume: 16, anno: 1996,
pagine: 5762 - 5776
SICI:
0270-6474(1996)16:18<5762:IAMBOA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE; VISUAL-CORTEX; RHESUS-MONKEY; GABA; SYSTEM; MOUSE; BRAIN; IMMUNOREACTIVITY; NEUROGENESIS; MICE;
Keywords:
NEOCORTICAL NEURONOGENESIS; CELL CYCLE; PROLIFERATION; NEURONAL MIGRATION; MOUSE; VENTRICULAR ZONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
T. Takahashi et al., "INTERKINETIC AND MIGRATORY BEHAVIOR OF A COHORT OF NEOCORTICAL NEURONS ARISING IN THE EARLY EMBRYONIC MURINE CEREBRAL WALL", The Journal of neuroscience, 16(18), 1996, pp. 5762-5776

Abstract

Neocortical neuronogenesis occurs in the pseudostratified ventricularepithelium (PVE) where nuclei of proliferative cells undergo interkinetic nuclear movement. A fraction of daughter cells exits the cell cycle as neurons (the quiescent, or Q, fraction), whereas a complementaryfraction remains in the cell cycle (the proliferative, or P, fraction). By means of sequential thymidine and bromodeoxyuridine injections in mouse on embryonic day 14, we have monitored the proliferative and post-mitotic migratory behaviors of 1 and 2 hr cohorts of PVE cells defined by the injection protocols. Soon after mitosis, the Q fraction partitions into a rapidly exiting (up to 50 mu m/hr) subpopulation (Q(r)) and a more slowly exiting (6 mu m/hr) subpopulation (Q(s)). Q(r) andQ(s) are separated as two distributions on exit from the ventricular zone with an interpeak distance of similar to 40 mu m. Cells in Q(r) and Q(s) migrate through the intermediate zone with no significant change in the interpeak distance, suggesting that they migrate at approximately the same velocities. The rate of migration increases with ascentthrough the intermediate zone (average 2-6.4 mu m/hr) slowing only transiently on entry into the developing cortex. Within the cortex, Q(r)and Q(s) merge to form a single distribution most concentrated over layer V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:07:17