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Titolo:
CEFTRIAXONE IN AMYOTROPHIC-LATERAL-SCLEROSIS
Autore:
BEGHI E; PRESTI ML; MANZONI C; MENNINI T; CAVESTRO C; POLONI M; MICHELI A; PINELLI P; MAI R; FACCHETTI D; TESTA D; CORNELIO F; MAZZINI L; BALZARINI C; MORA G; CHIO A; SCHIFFER D; TONALI P; SABATELLI M; MIGNOGNA T; LIPPI G; MANFREDI M; INGHILLERI M; MUSICCO M;
Indirizzi:
MARIO NEGRI INST PHARMACOL RES,LAB FARMACOL RECETTORIALE,VIA ERITREA 62 I-20157 MILAN ITALY OSPED SAN GERARDO MONZA ITALY OSPED CASO SOLLIERO SAN GIOVANNI ROTO ITALY UNIV MILAN,CLIN NEUROL 1,OSPED S PAOLO MILAN ITALY FDN CLIN LAVORO,CTR MED GUSSAGO PADUA ITALY IST NAZL NEUROL C BESTA MILAN ITALY FDN CLIN LAVORO,CTR MED VERUNO PADUA ITALY UNIV TURIN,NEUROL CLIN 2 TURIN ITALY CATHOLIC UNIV ROME,NEUROL CLIN ROME ITALY UNIV ROMA LA SAPIENZA,CLIN NEUROL 5 ROME ITALY CNR,IST TECNOL BIOMED AVANZATE I-20131 MILAN ITALY
Titolo Testata:
European journal of neurology
fascicolo: 4, volume: 3, anno: 1996,
pagine: 295 - 298
SICI:
1351-5101(1996)3:4<295:CIA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD; IMPROVEMENT; DISEASE;
Keywords:
CEFTRIAXONE; AMYOTROPHIC LATERAL SCLEROSIS; GLUTAMATE UPTAKE; SPINAL CORD SYNAPTOSOMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
E. Beghi et al., "CEFTRIAXONE IN AMYOTROPHIC-LATERAL-SCLEROSIS", European journal of neurology, 3(4), 1996, pp. 295-298

Abstract

One hundred and eight patients with amyotrophic lateral sclerosis (ALS) received ceftriaxone 2 g daily i.v. (62) or i.m. (34) or by both routes (12), for 21-day cycles on an open basis, Baseline MRC and Norrisscores were similar to those at the end of the first 21-day cycle of therapy, Seven patients showed remarkable clinical improvement, mostlysegmental, which started during the first week of treatment and lasted up to 2 months after its completion, Improvement was also noted in seven out of 21 cases given a subsequent cycle of treatment. Based on these findings, the drug is supposed to act by altering the neurochemical transmission at the neuromuscular junction and/or by facilitating the presynaptic uptake of glutamate at the synaptic junction, This hypothesis positively correlates with the results of in vitro experiments showing that ceftriaxone increases H-3-glutamate uptake in rat spinal cord synaptosomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:08:55