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Titolo:
FAMILIAL RISK OF LUNG-CANCER AMONG NONSMOKERS AND THEIR RELATIVES
Autore:
SCHWARTZ AG; YANG P; SWANSON GM;
Indirizzi:
ALLEGHENY SINGER RES INST,DEPT HUMAN GENET,320 E N AVE PITTSBURGH PA 15212 UNIV PITTSBURGH,SCH MED,DEPT FAMILY MED & CLIN EPIDEMIOL PITTSBURGH PA 00000 UNIV PITTSBURGH,CANC INST PITTSBURGH PA 00000 MICHIGAN STATE UNIV,CTR CANC E LANSING MI 48824 MICHIGAN STATE UNIV,COLL HUMAN MED E LANSING MI 48824
Titolo Testata:
American journal of epidemiology
fascicolo: 6, volume: 144, anno: 1996,
pagine: 554 - 562
SICI:
0002-9262(1996)144:6<554:FROLAN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-ENVIRONMENTAL INTERACTIONS; OBSTRUCTIVE PULMONARY-DISEASE; PASSIVE SMOKING; CIGARETTE-SMOKING; MEDICAL HISTORY; UNITED-STATES; SUSCEPTIBILITY; WOMEN; POLYMORPHISM; INFORMATION;
Keywords:
FAMILY HEALTH; GENETICS; LUNG DISEASES; LUNG NEOPLASMS; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Schwartz et al., "FAMILIAL RISK OF LUNG-CANCER AMONG NONSMOKERS AND THEIR RELATIVES", American journal of epidemiology, 144(6), 1996, pp. 554-562

Abstract

The role of family history of lung cancer in predicting lung cancer risk among nonsmokers and their relatives was evaluated in a population-based family study conducted in metropolitan Detroit. Lung cancer risk factor data were collected through telephone interviews with 257 nonsmoking lung cancer cases 40-84 years of age diagnosed between 1984 and 1987, their 2,252 relatives, 277 nonsmoking controls, and their 2,408 relatives. Lung cancer in a first-degree relative was associated with a 7.2-fold (95% confidence interval 1.3-39.7) increased risk of lungcancer among nonsmokers in the 40- to 59-year-old age group. This significant increased risk remained after adjustment for the smoking, occupational, and medical history of each family member (relative risk = 6.1, 95% confidence interval 1.1-33.4). Offspring of nonsmoking cases comprised another lung cancer high risk group (relative risk = 7.2, 95% confidence interval 0.5-103). A positive family history did not increase lung cancer risk among nonsmokers 60-84 years of age or their relatives. These findings suggest that susceptibility to lung cancer in families of nonsmoking cases may be evident only in a subset. of relatives of early-onset nonsmoking cases.

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Documento generato il 10/07/20 alle ore 15:57:36