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Titolo:
EXERCISE TRAINING ALTERS KINETICS OF ANTIOXIDANT ENZYMES IN RAT-TISSUES
Autore:
SOMANI SM; HUSAIN K;
Indirizzi:
SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL,POB 19230 SPRINGFIELD IL 62794
Titolo Testata:
Biochemistry and molecular biology international
fascicolo: 3, volume: 38, anno: 1996,
pagine: 587 - 595
SICI:
1039-9712(1996)38:3<587:ETAKOA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-PEROXIDASE; HUMAN-PLASMA; PURIFICATION; SYSTEM; RESPONSES;
Keywords:
MICHAELIS-MENTEN CONSTANT; MAXIMUM VELOCITY; CATALASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; EXERCISE; TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Somani e K. Husain, "EXERCISE TRAINING ALTERS KINETICS OF ANTIOXIDANT ENZYMES IN RAT-TISSUES", Biochemistry and molecular biology international, 38(3), 1996, pp. 587-595

Abstract

Michaelis-Menten constant (K-m) and maximum velocity (V-max) of catalase(CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) in various tissues of exercise-trained old rats were compared with the age matched sedentary control. Exercise training increased the maximum velocity (V-max) for CAT in the brain (350%), liver (33%), lung (34%), muscle (25%) and testes (21%); for GSH-Px (using t-butyl hydroperoxide as a substrate) in the liver (22%), lung (25%), and testes (52%); for GSH-Px (using GSH as a cosubstrate) in the brain (64%) and liver(100%), and for GR in testes (50%). This increase in V-max indicates the potential activation of these enzymes in the specific tissues. Exercise training differentially altered the affinities of enzyme (K-m) for CAT, GSH-Px and GR to their substrates. These studies suggest that exercise training provided a beneficial role by activation of antioxidant enzymes in specific tissues of aged rats. Thus, exercise training aids in coping with oxidative stress in old age.

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Documento generato il 10/07/20 alle ore 03:11:41