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Titolo:
X-CHROMOSOME AND INFANTILE-AUTISM
Autore:
PETIT E; HERAULT J; RAYNAUD M; CHERPI C; PERROT A; BARTHELEMY C; LELORD G; MUH JP;
Indirizzi:
CHU BRETONNEAU,LAB BIOCHIM & BIOL MOL PR MUH,INSERM U316 F-37044 TOURS FRANCE CHU BRETONNEAU,DEPT NEUROPHYSIOL & PSYCHOPATHOL DEV F-37044 TOURS FRANCE
Titolo Testata:
Biological psychiatry
fascicolo: 6, volume: 40, anno: 1996,
pagine: 457 - 464
SICI:
0006-3223(1996)40:6<457:XAI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR ANALYSIS; ASSOCIATION; ABNORMALITIES; FAMILIES; GENETICS; MARKERS;
Keywords:
X CHROMOSOME; INFANTILE AUTISM; ASSOCIATION STUDY; ASSOCIATED DISEASES; FRAGILE X SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
E. Petit et al., "X-CHROMOSOME AND INFANTILE-AUTISM", Biological psychiatry, 40(6), 1996, pp. 457-464

Abstract

Family studies and epidemiologic data in autism show the involvement of genetic factors in the etiology of this syndrome. The frequent association of X chromosome with mental retardation and behavior disturbances raises the question of its implication in the etiology of autism. Several markers of X chromosome were tested in autistic and control populations by association study. The autistic population was submitted to an extensive clinical examination. For the DXS287 marker, chi(2) analysis showed a different allele distribution between control and patient groups, This difference was enhanced when children with the most severe autistic behaviors and the least serious cognitive disorders were selected for statistical comparison. To our knowledge, this is the first association study described using markers of X chromosome in infantile autism. These preliminary results encourage our research on thischromosome, which could be considered as a significant genetic component of the multifactorial etiology of autism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 16:01:16