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Titolo:
IMMUNOGLOBULIN-A ANTIBODIES AGAINST PSEUDOMONAS-AERUGINOSA IN THE TEAR FLUID OF CONTACT-LENS WEARERS
Autore:
CHENG KH; SPANJAARD L; RUTTEN H; DANKERT JI; POLAK BCP; KIJLSTRA A;
Indirizzi:
NETHERLANDS OPHTHALM RES INST,DEPT OPHTHALMOIMMUNOL,POB 12141 NL-1100AC AMSTERDAM NETHERLANDS UNIV AMSTERDAM,DEPT OPHTHALMOL AMSTERDAM NETHERLANDS UNIV AMSTERDAM,DEPT MICROBIOL AMSTERDAM NETHERLANDS UNIV AMSTERDAM,DEPT OPHTHALMOIMMUNOL AMSTERDAM NETHERLANDS ROTTERDAM EYE HOSP ROTTERDAM NETHERLANDS
Titolo Testata:
Investigative ophthalmology & visual science
fascicolo: 10, volume: 37, anno: 1996,
pagine: 2081 - 2088
SICI:
0146-0404(1996)37:10<2081:IAAPIT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULCERATIVE KERATITIS; SECRETORY IGA; OVERNIGHT WEAR; RISK; ADHERENCE; CORNEA; USERS; LIPOPOLYSACCHARIDE; INFECTION; BINDING;
Keywords:
CONTACT LENS; KERATITIS; PSEUDOMONAS AERUGINOSA; SECRETORY IMMUNOGLOBULIN A; TEARS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K.H. Cheng et al., "IMMUNOGLOBULIN-A ANTIBODIES AGAINST PSEUDOMONAS-AERUGINOSA IN THE TEAR FLUID OF CONTACT-LENS WEARERS", Investigative ophthalmology & visual science, 37(10), 1996, pp. 2081-2088

Abstract

Purpose. Pseudomonas aeruginosa is the most important cause of contact lens-associated ulcerative keratitis, especially for those who use extended-wear lenses. Until now, the presence of specific anti-P. aeruginosa immunoglobulin A (IgA) antibodies in the tears of contact lens wearers has not been investigated and is the purpose of the current study. Methods. The levels of specific IgA antibodies against P. aeruginosa and total secretory IgA (s-IgA) concentrations were measured in tears of various groups of contact lens and noncontact lens wearers usingenzyme-linked immunosorbent assays. Contact lens groups were divided into the following categories: daily-wear rigid gas-permeable lenses (n = 23), daily-wear soft lenses (n = 22), extended-wear soft lenses (n= 17), and noncontact lens wearers (n = 23). As a positive control group, we tested tears obtained from patients with cystic fibrosis (n = 5) because the respiratory tract of these persons often are colonized by P. aeruginosa. Results, The percentage of nonresponders (<15 U/ml) varied between 9% in daily-wear rigid gas-permeable contact lens usersto 23% in daily wear soft contact lens users, The percentage of nonresponders in controls was 13%. The frequency of nonresponders was not significantly different among the different groups tested. All patientswith cystic fibrosis showed a very high anti-P. aeruginosa IgA response in their tears. When analyzing the mean anti-P. aeruginosa IgA response, a significantly lower level was found in extended-wear contact lens users (38 U/ml) compared to noncontact lens wearers (82 U/ml). Total s-IgA levels in the tears of the various groups tested were not significantly different. Conclusions. A substantial number of persons in the population of contact lens wearers tested lack detectable IgA antibodies against P. aeruginosa in their tears and may be susceptible to P. aeruginosa keratitis if the physiological condition of their corneais compromised.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:46:33