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Titolo:
THE HUD PARANEOPLASTIC PROTEIN SHARES IMMUNOGENIC REGIONS BETWEEN PEMPSN PATIENTS AND SEVERAL STRAINS AND SPECIES OF EXPERIMENTAL-ANIMALS/
Autore:
SMITT PS; MANLEY G; DALMAU J; POSNER J;
Indirizzi:
DR DANIEL DEN HOED CANC CTR,DEPT NEUROONCOL NL-3008 AE ROTTERDAM NETHERLANDS MEM SLOAN KETTERING CANC CTR,DEPT NEUROL NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,COTZIAS LAB NEUROONCOL NEW YORK NY 10021 CORNELL UNIV,COLL MED,DEPT NEUROL & NEUROSCI NEW YORK NY 10021
Titolo Testata:
Journal of neuroimmunology
fascicolo: 1-2, volume: 71, anno: 1996,
pagine: 199 - 206
SICI:
0165-5728(1996)71:1-2<199:THPPSI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENCEPHALOMYELITIS SENSORY NEURONOPATHY; CENTRAL-NERVOUS-SYSTEM; CELL LUNG-CANCER; ANTIBODY; BINDING; TUMOR; RNA; EXPRESSION; DROSOPHILA; ANTIGENS;
Keywords:
ANTI-HU ANTIBODIES; PARANEOPLASTIC DISEASE; EXPERIMENTAL ANIMALS; SJL MICE; AUTOIMMUNE DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P.S. Smitt et al., "THE HUD PARANEOPLASTIC PROTEIN SHARES IMMUNOGENIC REGIONS BETWEEN PEMPSN PATIENTS AND SEVERAL STRAINS AND SPECIES OF EXPERIMENTAL-ANIMALS/", Journal of neuroimmunology, 71(1-2), 1996, pp. 199-206

Abstract

Patients with small-cell carcinoma of the lung and paraneoplastic encephalomyelitis develop antibodies (anti-Hu) against HuD, a member of afamily of neuronal specific RNA-binding proteins, which are also expressed by the tumor. In order to determine if the human HuD paraneoplastic antigen shares immunogenic regions between patients and several strains and species of animals, we immunized animals with HuD and several deletion constructs of this protein. All immunized animals developedhigh titers of anti-HuD antibodies, comparable to the antibody titersfound in paraneoplastic patients. Using immunohistochemistry and Western blot analysis of human and mouse cerebral cortex, the pattern of reactivity of these antibodies could not be differentiated from the human paraneoplastic anti-Hu antibodies. None of the immunized animals developed neurologic symptoms. Western blot analysis of HuD deletion constructs demonstrated that the first and second RNA binding domains were the main immunodominant regions, and that the animal immune responsewas both strain and species dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:43:31