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Titolo:
COMPLEMENT EXPRESSION ON ASTROCYTES AND ASTROCYTOMA CELL-LINES - FAILURE OF COMPLEMENT REGULATION AT THE C3 LEVEL CORRELATES WITH VERY-LOW CD55 EXPRESSION
Autore:
SPILLER OB; MORETTO G; KIM SU; MORGAN BP; DEVINE DV;
Indirizzi:
UNIV WALES COLL MED,DEPT BIOCHEM MED CARDIFF CF4 4XN S GLAM WALES UNIV BRITISH COLUMBIA,DEPT MED,DIV NEUROL VANCOUVER BC CANADA UNIV BRITISH COLUMBIA,DEPT PATHOL VANCOUVER BC CANADA CANADIAN RED CROSS BLOOD TRANSFUS SERV VANCOUVER BC CANADA
Titolo Testata:
Journal of neuroimmunology
fascicolo: 1-2, volume: 71, anno: 1996,
pagine: 97 - 106
SICI:
0165-5728(1996)71:1-2<97:CEOAAA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DECAY-ACCELERATING FACTOR; MEMBRANE COFACTOR PROTEIN; C-3 CONVERTASES; BRAIN-TISSUE; MULTIPLE-SCLEROSIS; ALZHEIMERS-DISEASE; GENE-EXPRESSION; FACTOR DAF; ACTIVATION; PATHWAY;
Keywords:
ASTROCYTE; CD59; CD55; CD46; COMPLEMENT; GLIOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
O.B. Spiller et al., "COMPLEMENT EXPRESSION ON ASTROCYTES AND ASTROCYTOMA CELL-LINES - FAILURE OF COMPLEMENT REGULATION AT THE C3 LEVEL CORRELATES WITH VERY-LOW CD55 EXPRESSION", Journal of neuroimmunology, 71(1-2), 1996, pp. 97-106

Abstract

Primary fetal human astrocytes and an astrocytoma cell line, U373-MG,expressed membrane cofactor protein (CD46), CD59, and low levels of decay-accelerating factor (CD55). Astrocyte CD55 was capable of regulating C3 deposition on the cell surface; albeit at a lower level than primary human fibroblasts. Negligible complement mediated lysis of primary astrocytes and the U373-MG cell line was observed, even when large amount of astrocyte-specific, complement-activating antibodies were bound to the cells. Blocking the function of CD59 on astrocytes resultedin a > 90% cell lysis, while equivalent lysis of fibroblasts could only be achieved with additional blocking of CD55.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:02:46