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Titolo:
DOUBLE-BLIND COMPARISON OF CABERGOLINE AND BROMOCRIPTINE IN PARKINSONS-DISEASE PATIENTS WITH MOTOR FLUCTUATIONS
Autore:
INZELBERG R; NISIPEANU P; RABEY JM; ORLOV E; CATZ T; KIPPERVASSER S; SCHECHTMAN E; KORCZYN AD;
Indirizzi:
TEL AVIV UNIV,SACKLER FAC MED,SIERATZKI CHAIR NEUROL IL-69978 RAMAT AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED,SIERATZKI CHAIR NEUROL IL-69978 RAMAT AVIV ISRAEL TEL AVIV UNIV,TEL AVIV MED CTR,DEPT NEUROL IL-69978 RAMAT AVIV ISRAEL WEIZMANN INST SCI,CTR COMP IL-76100 REHOVOT ISRAEL
Titolo Testata:
Neurology
fascicolo: 3, volume: 47, anno: 1996,
pagine: 785 - 788
SICI:
0028-3878(1996)47:3<785:DCOCAB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTING DOPAMINE AGONIST; TOLERABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
R. Inzelberg et al., "DOUBLE-BLIND COMPARISON OF CABERGOLINE AND BROMOCRIPTINE IN PARKINSONS-DISEASE PATIENTS WITH MOTOR FLUCTUATIONS", Neurology, 47(3), 1996, pp. 785-788

Abstract

In the present study we compared the efficacy and safety of the new dopamine agonist-cabergoline (CBG) with bromocriptine (BCR) in Parkinson's disease (PD). CBG has a very long half-life and can be administered as a single daily dose. Forty-four PD patients with uncontrolled motor fluctuations participated in the study. Patients were randomly and blindly assigned to equivalent doses of either CBG or BCR in addition to preexisting levodopa. Dosage was titrated to optimal, using up to 6mg of CBG or 40 mg of BCR daily. CBG was given as a single morning dose whereas BCR was administered tid. Sixteen patients were followed for 1 year and 16 additional patients for 6 months. The mean follow-up duration was 9 +/- 5 months. The main effect of both drugs was observedon motor UPDRS scores, rigidity, bradykinesia items, and the percentage of awake hours spent during ''on'' and ''off. '' In general, the effect of CBG was similar to that of BCR. The percentage of awake hours spent during ''on'' was higher with CBG as compared with BCR. Adverse events included dyskinesias, orthostatism, confusion, edema, and paresthesias in limbs. These effects were seen at similar frequencies with both drugs. The study shows that CBG given as a single morning dose is at least as efficacious as BCR given tid. CBG is a promising dopamine agonist for the treatment-of motor fluctuations in PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:49:26