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Titolo:
SEX-HORMONES PROLONG THE QT INTERVAL AND DOWN-REGULATE POTASSIUM CHANNEL EXPRESSION IN THE RABBIT HEART
Autore:
DRICI MD; BURKLOW TR; HARIDASSE V; GLAZER RI; WOOSLEY RL;
Indirizzi:
GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL,3900 RESERVOIR RD NW WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL WASHINGTON DC 20007 CHILDRENS NATL MED CTR,DEPT CARDIOL WASHINGTON DC 20010
Titolo Testata:
Circulation
fascicolo: 6, volume: 94, anno: 1996,
pagine: 1471 - 1474
SICI:
0009-7322(1996)94:6<1471:SPTQIA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
K+-CHANNEL; MESSENGER-RNA; RAT-HEART; VENTRICULAR REPOLARIZATION; DIFFERENTIAL EXPRESSION; CARDIAC-ARRHYTHMIA; TERFENADINE; MECHANISM; INDUCTION; PREGNANCY;
Keywords:
POTASSIUM; HORMONES; SEX; ELECTROPHYSIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Drici et al., "SEX-HORMONES PROLONG THE QT INTERVAL AND DOWN-REGULATE POTASSIUM CHANNEL EXPRESSION IN THE RABBIT HEART", Circulation, 94(6), 1996, pp. 1471-1474

Abstract

Background Sex hormones are known to exert direct and indirect effects on cardiovascular function, but their effects on cardiac repolarization have not been elucidated. The repolarization phase of the cardiac action potential or QT interval of the ECG is regulated largely by potassium channels such as the delayed rectifier currents HK2 and I-sK. Methods and Results The effects of ovariectomy (OVX) and estradiol (E2)or dihydrotestosterone (DHT) treatment were evaluated on HK2, HERG, and I-sK (mRNA levels, QT duration, and quinidine-induced changes in QTinterval in isolated rabbit hearts. HK2 and 0.7-kilobase I-sK mRNA were downregulated in cardiac ventricular tissue from OVX rabbits treated with either E2 or DHT. The QT interval was prolonged in E2- and DHTtreated animals (OVX+vehicle, 223+/-6 ms; OVX+DHT, 236+/-10 ms; and OVXDHT, 245+/-6 ms; P<.05). Conclusions The association between hormone-induced changes in baseline QT interval and the mRNA level for these channels suggests that sex hormones may play a critical role in regulating cardiac repolarization. However, the changes in baseline QT and potassium channel mRNA after hormone treatment were not concordant with the changes in QT interval alter the infusion of quinidine, after which E2-treated animals responded similarly to controls (18.4+/-4.6% and 19.3+4.6% increase in QT interval, respectively) and DHT-treated animals exhibited less QT prolongation (11.4+/-3.8% increase; P<.03).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 00:56:07