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Titolo:
MODULATION OF ATRIAL REPOLARIZATION BY SITE OF PACING IN THE ISOLATEDRABBIT HEART
Autore:
WOOD MA; MANGANO RA; SCHIEKEN RM; BAUMGARTEN CM; SIMPSON PM; ELLENBOGEN KA;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT INTERNAL MED CARDIOL,BOX 980053 RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PEDIAT CARDIOL RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHYSIOL RICHMOND VA23298 WAYNE STATE UNIV,DEPT PEDIAT DETROIT MI 48202
Titolo Testata:
Circulation
fascicolo: 6, volume: 94, anno: 1996,
pagine: 1465 - 1470
SICI:
0009-7322(1996)94:6<1465:MOARBS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-WAVE; CARDIAC MEMORY; FIBRILLATION; MECHANISM; THERAPY; GENESIS;
Keywords:
PACING; ATRIUM; ACTION POTENTIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Wood et al., "MODULATION OF ATRIAL REPOLARIZATION BY SITE OF PACING IN THE ISOLATEDRABBIT HEART", Circulation, 94(6), 1996, pp. 1465-1470

Abstract

Background Single-site or multisite atrial pacing may reduce the incidence of atrial fibrillation in humans. The therapeutic mechanisms mayinclude synchronization of atrial repolarization (repolarization ''memory'') and/or decreased dispersion of atrial repolarization. These responses have not been well documented in intact atria. Methods and Results Monophasic action potential recordings were made from six atrial epicardial sites in 39 isolated perfused rabbit heart preparations during 3 hours of continuous right atrial, left atrial, or biatrial pacing. Action potential recordings obtained at times 0, 45, 90, 135, and 180 minutes were computer analyzed for activation time (AT) and 90% action potential duration (APD) at each site. No consistent relationship could be demonstrated between APD and AT at any time during atrial pacing (all P>.05). On average, left atrial APDs were longer than right atrial APDs by up to 6.3 ms at all times, regardless of the site of pacing (P less than or equal to.05). At all times, dispersion of atrial repolarization was minimized by left atrial pacing compared with right atrial pacing (21.6+/-9.1 versus 32.4+/-15.1 ms, respectively, at time0; P<.05). Biatrial pacing provided no further reduction in dispersion of repolarization compared with left atrial pacing (all P>.05). Conclusions No relationship can be demonstrated between atrial AT and APD in the isolated rabbit heart preparation. This differs from ventricular repolarization ''memory,'' which is demonstrable under the same conditions. Left atrial APD is, on average, longer than right atrial APD, suggesting spatial heterogeneity in repolarization. Dispersion of atrial repolarization is minimized by left atrial pacing in this preparation with no further advantage to biatrial pacing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:42:10