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Titolo:
AUDIOVESTIBULAR FINDINGS IN PATIENTS WITH DEAFNESS CAUSED BY A MITOCHONDRIAL SUSCEPTIBILITY MUTATION AND PRECIPITATED BY AN INHERITED NUCLEAR MUTATION OR AMINOGLYCOSIDES
Autore:
BRAVERMAN I; JABER L; LEVI H; ADELMAN C; ARONS KS; FISCHELGHODSIAN N; SHOHAT M; ELIDAN J;
Indirizzi:
HADASSAH UNIV HOSP,DEPT OTOLARYNGOL IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT OTOLARYNGOL HEAD & NECK SURG IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,SPEECH & HEARING CTR IL-91120 JERUSALEM ISRAEL TEL AVIV UNIV,SCH MED,BASIL & GERALD FELSENSTEIN MED RES CTR,DEPT PEDIAT IL-49100 PETAH TIQWA ISRAEL TEL AVIV UNIV,SCH MED,BASIL & GERALD FELSENSTEIN MED RES CTR,DEPT MEDGENET IL-49100 PETAH TIQWA ISRAEL GALLAUDET UNIV,GALLAUDET RES INST,GENET SERV CTR WASHINGTON DC 20002 UNIV CALIF LOS ANGELES LOS ANGELES CA 00000 CEDARS SINAI RES INST,CTR MED GENET BIRTH DEFECTS,STEVEN SPIELBERG PEDIAT RES CTR LOS ANGELES CA 00000
Titolo Testata:
Archives of otolaryngology, head & neck surgery
fascicolo: 9, volume: 122, anno: 1996,
pagine: 1001 - 1004
SICI:
0886-4470(1996)122:9<1001:AFIPWD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORINEURAL DEAFNESS; MATERNAL INHERITANCE; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
I. Braverman et al., "AUDIOVESTIBULAR FINDINGS IN PATIENTS WITH DEAFNESS CAUSED BY A MITOCHONDRIAL SUSCEPTIBILITY MUTATION AND PRECIPITATED BY AN INHERITED NUCLEAR MUTATION OR AMINOGLYCOSIDES", Archives of otolaryngology, head & neck surgery, 122(9), 1996, pp. 1001-1004

Abstract

Objective: To characterize the audiological and vestibular changes associated with a mitochondrial DNA mutation in an Arab-Israeli family and in other families with mitochondrial predisposition to aminoglycoside-induced hearing loss. Design: Evaluation of audiological (pure tonethresholds, speech reception thresholds, speech discrimination, tympanometry, acoustic reflex thresholds, tone decay, and auditory brain-stem evoked response recording) and vestibular (complete history, physical examination, and 2-channel electronystagmography) systems. In 5 patients, structural evaluation of the inner ear was done by magnetic resonance imaging. Patients: Fifteen members of an Arab-Israeli family, and 1 Chinese woman with the same mitochondrial DNA mutation who experienced hearing loss after short-term exposure to streptomycin. Results:Most of the patients had a profound hearing loss due to cochlear involvement. The hearing loss usually was not accompanied by notable peripheral vestibular dysfunction. In the patient with severe hearing loss after exposure to aminoglycoside, the vestibular function was completely normal. Conclusions: In most of the Arab-Israeli patients with congenital deafness, the vestibular system function was normal, in contrast to the frequency of vestibular abnormality among deaf children, which was described in the literature. This may be related to genetic predisposition to aminoglycoside-induced deafness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:24:39