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Titolo:
LITHIUM COMPARED TO VALPROIC ACID AND CARBAMAZEPINE IN THE TREATMENT OF MANIA - A STATISTICAL METAANALYSIS
Autore:
EMILIEN G; MALOTEAUX JM; SEGHERS A; CHARLES G;
Indirizzi:
EUROPEAN CR&D DEPT,80 AVE PRESIDENT WILSON F-92031 PARIS FRANCE BRISTOL MYERS SQUIBB B-1410 WATERLOO BELGIUM UNIV CATHOLIQUE LOUVAIN,CLIN UNIV ST LUC,DEPT NEUROL,PHARMACOL LAB B-1200 BRUSSELS BELGIUM UNIV CATHOLIQUE LOUVAIN,CLIN UNIV ST LUC,DEPT PSYCHIAT B-1200 BRUSSELS BELGIUM
Titolo Testata:
European neuropsychopharmacology
fascicolo: 3, volume: 6, anno: 1996,
pagine: 245 - 252
SICI:
0924-977X(1996)6:3<245:LCTVAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPHYLAXIS; EFFICACY; PLACEBO; TRIALS; DRUGS;
Keywords:
LITHIUM; CARBAMAZEPINE; VALPROIC ACID; MANIC DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
G. Emilien et al., "LITHIUM COMPARED TO VALPROIC ACID AND CARBAMAZEPINE IN THE TREATMENT OF MANIA - A STATISTICAL METAANALYSIS", European neuropsychopharmacology, 6(3), 1996, pp. 245-252

Abstract

The hypothesis that lithium is the most appropriate and efficacious pharmacological treatment in the therapy of manic-depressive illness was examined in a meta-analysis. The efficacy of lithium was compared with that of the antiepileptics, carbamazepine and valproic acid. Data sources include the Medline database and relevant references from articles. Only randomised controlled clinical trials with a double-blind assessment of outcomes were included. Lithium levels were required to bewithin the therapeutic range of 0.4-1.5 mmol/l. The effect sizes weremeasured by the odds ratio using the Mantel-Haenszel method. No significant difference was observed between the treatment effect of the 3 drugs compared. While the efficacy of the 3 treatments was identical, there is a general tendency in favour of the antiepileptics in the treatment of manic depression with regard to adverse events and treatment tolerance. The impact and importance of this study seriously question the relevance of today's practice of prescribing lithium in the acute management of manic-depressive illness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:40:38