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Titolo:
INDUCTION OF C-FOS GENE-EXPRESSION BY THE SELECTIVE SIGMA-RECEPTOR LIGAND EMD-57445 IN RAT-BRAIN
Autore:
DAHMEN N; FISCHER V; HODL P; RUJESCU D; REUSS S; BARTOSZYK GD; HIEMKE C;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY UNIV MAINZ,DEPT PSYCHIAT D-55131 MAINZ GERMANY UNIV MAINZ,DEPT ANAT D-55099 MAINZ GERMANY E MERCK AG,DEPT CNS RES D-64271 DARMSTADT GERMANY
Titolo Testata:
European neuropsychopharmacology
fascicolo: 3, volume: 6, anno: 1996,
pagine: 237 - 243
SICI:
0924-977X(1996)6:3<237:IOCGBT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; BINDING-SITES; AUTORADIOGRAPHIC LOCALIZATION; HALOPERIDOL; DOPAMINE; PROTEIN; SCHIZOPHRENIA; FOREBRAIN; NEUROLEPTICS; CLOZAPINE;
Keywords:
NEUROLEPTICS; SIGMA BINDING SITES; C-FOS; EMD 57445;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
N. Dahmen et al., "INDUCTION OF C-FOS GENE-EXPRESSION BY THE SELECTIVE SIGMA-RECEPTOR LIGAND EMD-57445 IN RAT-BRAIN", European neuropsychopharmacology, 6(3), 1996, pp. 237-243

Abstract

Based on animal studies it has been reasoned that ligands to sigma binding sites might be effective in the treatment of schizophrenic disorders and may also be used to investigate this largely elusive disorderon a molecular level. Expression patterns of c-fos in rat brain were studied following treatment with single doses of the sigma ligand EMD 57445 (0.3, 1, 3, 30 mg/kg s.c.). Specific c-fos gene expression was detected at all concentrations tested in various cortical areas. The signals observed were dose-dependent with the highest intensities in thepiriform cortex. Strong signals were also detected in hippocampal areas CA 1,2,3 and the gyrus dentatus, as well as in the medial habenula nuclei. In the caudate putamen, nucleus accumbens and lateral septal nucleus signals were detectable after administration of doses greater than or equal to 1 mg/kg. Furthermore, c-fos hybridization was visible in the amygdala,in the mammillary bodies, the islands of Calleja and in the olfactory tubercle. In the hypothalamus, c-fos expression was seen in the median eminence area after 30 mg/kg EMD 57445. No hybridization signals were obtained in brainstem or cerebellum. Since c-fos expression induced by EMD 57445 resembled the pattern obtained with atypical neuroleptics and studies on animal behavior point to antipsychotic activity, it is concluded that the drug might be suitable in the treatment of schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:29:07