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Titolo:
THE ROLE OF CYTOCHROME-P450 2D6 IN THE METABOLISM OF MOCLOBEMIDE
Autore:
HARTTER S; DINGEMANSE J; BAIER D; ZIEGLER G; HIEMKE C;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY UNIV MAINZ,DEPT PSYCHIAT D-55131 MAINZ GERMANY F HOFFMANN LA ROCHE & CO LTD,DEPT CLIN PHARMACOL CH-4002 BASEL SWITZERLAND HOFFMANN LA ROCHE INC GRENZACH WYHLEN GERMANY INST PSYCHOSOMAT RES STUTTGART GERMANY
Titolo Testata:
European neuropsychopharmacology
fascicolo: 3, volume: 6, anno: 1996,
pagine: 225 - 230
SICI:
0924-977X(1996)6:3<225:TROC2I>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
A INHIBITOR MOCLOBEMIDE; DRUG-METABOLISM; GENETIC-POLYMORPHISM; REUPTAKE INHIBITORS; IN-VITRO; PHARMACOKINETICS; DEXTROMETHORPHAN; CYP2D6; HYDROXYLATION; VOLUNTEERS;
Keywords:
MOCLOBEMIDE; MAO-A INHIBITOR; DRUG METABOLISM; CYP2D6; PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S. Hartter et al., "THE ROLE OF CYTOCHROME-P450 2D6 IN THE METABOLISM OF MOCLOBEMIDE", European neuropsychopharmacology, 6(3), 1996, pp. 225-230

Abstract

The metabolic fate of moclobemide (Ro 11-1163), a new reversible and selective inhibitor of monoamine oxidase type A (MAO-A), has been assessed in a pilot study in 2 debrisoquine poor metabolizers (PM) and 4 extensive metabolizers (EM) after multiple oral dosings of moclobemide with and without co-medication of dextromethorphan. Absorption and disposition parameters were not different between PM and EM. Concurrent application of dextromethorphan, a selective substrate of CYP2D6, did not affect the pharmacokinetics of moclobemide. These results indicate that the cytochromal isoenzyme CYP2D6 does not play a major role in the metabolic degradation of moclobemide. Limited CYP2D6 activities because of a genetic defect or co-medications with CYP2D6 substrates should therefore not give rise to elevated moclobemide blood levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:52:30