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Titolo:
5HT(2C) RECEPTOR AGONISTS EXHIBIT ANTIDEPRESSANT-LIKE PROPERTIES IN THE ANHEDONIA MODEL OF DEPRESSION IN RATS
Autore:
MOREAU JL; BOS M; JENCK F; MARTIN JR; MORTAS P; WICHMANN J;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,PRECLIN CNS RES,DIV PHARMA CH-4002 BASELSWITZERLAND
Titolo Testata:
European neuropsychopharmacology
fascicolo: 3, volume: 6, anno: 1996,
pagine: 169 - 175
SICI:
0924-977X(1996)6:3<169:5RAEAP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS-INDUCED ANHEDONIA; UNPREDICTABLE MILD STRESS; ANIMAL-MODEL; 5-HT1C RECEPTORS; ANTAGONISTS; MIANSERIN; REVERSAL; FLUOXETINE; PREFERENCE; DRUGS;
Keywords:
ANHEDONIA; 5HT(2C); RECEPTOR AGONISTS; REWARD; DEPRESSION; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Moreau et al., "5HT(2C) RECEPTOR AGONISTS EXHIBIT ANTIDEPRESSANT-LIKE PROPERTIES IN THE ANHEDONIA MODEL OF DEPRESSION IN RATS", European neuropsychopharmacology, 6(3), 1996, pp. 169-175

Abstract

Potential antidepressant properties of preferential 5HT(2c) receptor agonists were investigated in stress-induced anhedonia, a validated simulation of depression. This simulation evaluates the hedonic state ofstressed rats by recording variations in self-stimulation threshold measured before, during, and after exposure to intermittent, unpredictable, mind stressors. This stress regimen gradually elevates self-stimulation threshold, suggesting the development of an anhedonic state. Instressed animals, chronic treatment with the preferential 5HT(2C) receptor agonists Ro 60-0175 and Ro 60-0332 (3 mg/kg i.p, b.i.d.) prevented the loss of sensitivity to reward. Similarly, when stressed anhedonic animals were curatively treated with Ro 60-0175 (3 mg/kg i.p. b.i.d.), the stress-induced anhedonia was gradually reversed. These resultssuggest a role for 5HT(2C) receptors in some aspects of depression, and potential antidepressant properties for selective 5HT(2C) receptor agonists. Such compounds may offer an innovative approach to the treatment of mood disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:42:09