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Titolo:
HIV TYPE-1 PHENOTYPE CORRELATES WITH THE STAGE OF INFECTION IN VERTICALLY INFECTED CHILDREN
Autore:
BALOTTA C; VIGANO A; RIVA C; COLOMBO MC; SALVAGGIO A; DEPASQUALE MP; CRUPI L; PAPAGNO L; GALLI M; MORONI M; PRINCIPI N;
Indirizzi:
UNIV MILAN,L SACCO HOSP VIALBA,INFECT DIS CLIN,VIA GB GRASSI 74 I-20157 MILAN ITALY UNIV MILAN,CLIN MALATTIE INFETT I-20157 MILAN ITALY UNIV MILAN,CATTEDRA PEDIAT 4 I-20157 MILAN ITALY UNIV MILAN,INST IGIENE & MED PREVENT I-20157 MILAN ITALY
Titolo Testata:
AIDS research and human retroviruses
fascicolo: 13, volume: 12, anno: 1996,
pagine: 1247 - 1253
SICI:
0889-2229(1996)12:13<1247:HTPCWT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; BIOLOGICAL PHENOTYPE; DISEASE PROGRESSION; VIRAL PHENOTYPE; INFANTS; AIDS; QUANTITATION; SURVIVAL; SEVERITY; VARIANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C. Balotta et al., "HIV TYPE-1 PHENOTYPE CORRELATES WITH THE STAGE OF INFECTION IN VERTICALLY INFECTED CHILDREN", AIDS research and human retroviruses, 12(13), 1996, pp. 1247-1253

Abstract

A cohort of 39 vertically infected children (class N, A, B, and C of the CDC HIV classification for pediatric infection) was studied by virus isolation and non-syncytium inducing (NSI)/syncytium inducing (SI) HIV-1 phenotype evaluation, The HIV-1 isolates were recovered from PBMCs and the MT-2 cell line was used to perform the syncytium assay. HIV-1 could be isolated in 34 of 39 (87%) infected children, regardless of the clinical and immunological stage of the disease, Class N and A subjects harbored exclusively NSI strains, whereas the SI phenotype wasdetected in two of eight class B and five of nine class C patients, All of the SI variants were observed in severely CD4-depleted children (class 3 patients). The capability of pediatric HIV-1 isolates to induce a cytopathic effect is associated with the clinical status and the degree of CD4 depletion, These data suggest that the biological properties of HIV-1 isolates in children do not differ from those observed in adults, and that viral phenotype strictly correlates with disease progression in vertically infected children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:15:37