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Titolo:
RAS SIGNALING IN TUMOR NECROSIS FACTOR-INDUCED APOPTOSIS
Autore:
TRENT JC; MCCONKEY DJ; LOUGHLIN SM; HARBISON MT; FERNANDEZ A; ANANTHASWAMY HN;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT IMMUNOL,1515 HOLCOMBE BLVD HOUSTON TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT IMMUNOL HOUSTON TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT CELL BIOL HOUSTON TX 77030
Titolo Testata:
EMBO journal
fascicolo: 17, volume: 15, anno: 1996,
pagine: 4497 - 4505
SICI:
0261-4189(1996)15:17<4497:RSITNF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS ENDONUCLEASE ACTIVATION; FACTOR-ALPHA; PROTEIN-KINASE; TNF-ALPHA; TYROSINE PHOSPHORYLATION; ONCOGENE EXPRESSION; SUPPRESSOR ACTIVITY; CELL-DEATH; C-MYC; FIBROBLASTS;
Keywords:
APOPTOSIS; ENDOGENOUS ENDONUCLEASE; RAS ACTIVATION; TUMOR NECROSIS FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Trent et al., "RAS SIGNALING IN TUMOR NECROSIS FACTOR-INDUCED APOPTOSIS", EMBO journal, 15(17), 1996, pp. 4497-4505

Abstract

Tumor necrosis factor (TNF) exerts cytotoxicity on many types of tumor cells but not on normal cells, The molecular events leading to cell death triggered by TNF are still poorly understood, Our previous studies have shown that enforced expression of an activated H-ras oncogene converted non-tumorigenic, TNF-resistant C3H 10T1/2 fibroblasts into tumorigenic cells that also became very sensitive to TNF-induced apoptosis, This finding suggested that Ras activation may play a role in TNF-induced apoptosis, In this study we investigated whether Ras activation is an obligatory step in TNF-induced apoptosis, Introduction of twodifferent molecular antagonists of Ras, the rap1A tumor suppressor gene or the dominant-negative rasN17 gene, into H-ras-transformed 10TEJ cells inhibited TNF-induced apoptosis, Similar results were obtained with L929 cells, a fibroblast cell line sensitive to TNF-induced apoptosis, which does not have a ras mutation, While Ras is constitutively activated in TNF-sensitive 10TEJ cells, TNF treatment increased Ras-bound GTP in TNF-sensitive L929 cells but not in TNF-resistant 10T1/2 cells, Moreover, RasN17 expression blocked TNF-induced Ras-GTP formation in L929 cells, These results demonstrate that Ras activation is required for TNF-induced apoptosis in mouse fibroblasts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:00:31